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Limbic system
ā€¢ ā€œLimbicā€œ from Latin word Limbus
ā€¢ Means "border" or "edge".
ā€¢ Separates
ā€¢ Medial surface of cerebral cortex
ā€¢ From diencephalon
ā€¢ Consists of
ā€¢ Grey matter
ā€¢ Cortical structures
ā€¢ Subcortical structures
ā€¢ White matter
ā€¢ Interconnecting fibre tracts
Grey matter
ā€¢ Limbic lobe
ā€¢ Hippocampal formation
ā€¢ Amygdala
ā€¢ Hypothalamus
ā€¢ Thalamus
ā€¢ Septal area
ā€¢ Habenular nuclei (epithalamus)
Limbic lobe
ā€¢ C-shaped ring of grey matter
ā€“ On medial surface of each cerebral
hemisphere
ā€¢ Surrounding the corpus callosum
ā€“ 1. Subcallosal area
ā€“ 2. Cingulate gyrus
ā€“ 3. Isthmus
ā€“ 4. Parahippocampal gyrus
ā€“ 5. Uncus
Subcallosal gyrus
ā€¢ A narrow lamina of grey matter
ā€¢ Lies
ā€¢ Infront of lamina terminalis
ā€¢ Behind the parolfactory area
Cingulate gyrus
ā€¢ Lies dorsal to
ā€¢ Corpus callosum
ā€¢ Receives inputs from
ā€¢ Anterior nucleus of thalamus
ā€¢ Projects to
ā€¢ Entorhinal cortex via cingulum
ā€¢ Involved with
ā€¢ Emotion formation and processing,
learning, and memory
ā€¢ Lesions lead to
ā€¢ Akinesia, mutism
Parahippocampal gyrus
Parahippocampus
ā€¢ Lies in medial temporal lobe
ā€¢ Medial to collateral sulcus
ā€¢ Important role
ā€¢ In memory encoding and retrieval
ā€¢ ERC
ā€¢ Funnels highly processed cortical
information
ā€¢ To hippocampal formation and serves
as its major output pathway
Uncus
ā€¢ 2 parts by tail of dentate gyrus
ā€¢ Uncinate gyrus
ā€¢ Intralimbic gyrus
Hippocampal formation
Hippocampus
Dentate gyrus
Gyrus
fasciolaris
ā€¢ Hippocampus
ā€¢ Dentate gyrus
ā€¢ (Which lies medial to hippocampus)
ā€¢ Gyrus fasciolaris
ā€¢ Indusium griseum
Cingulate gyrus
Indusium griseum
Hippocampus
ā€¢ Consolidation of new memories
ā€¢ Lies in
ā€¢ Floor & medial wall of
ā€¢ Inferior horn of lateral ventricle
Called as cornu ammonis
Ancient Egyptian deity,
Ammon
nferior horn of
Lateral ventricle
Hippocampus
ā€¢ The most sensitive
area in brain
ā€¢ For Ischemic events
in hippocampus is
CA1
ā€¢ Trilaminate structure
ā€¢ Molecular
ā€¢ Pyramidal
ā€¢ Polymorphic
Dentate gyrus
ā€¢ Longitudinal strip of grey matter
ā€¢ Lies
ā€¢ Medial to hippocampus
ā€¢ Fused with hippocampus
ā€¢ On its lateral margin
ā€¢ Medial margin is crenated
Dentate
gyrus
Dentate gyrus
ā€¢ Anteriorly it ends as tail
ā€¢ Runs across the inferior
surface of uncus
ā€¢ By that uncus is divided
into
ā€¢ Anterior uncinated
gyrus
ā€¢ Posterior intralimbic
gyrus
ā€¢ Posteriorly it continues
as
ā€¢ Gyrus fasciolaris
Gyrus fasciolaris & Indusium griseum
ā€¢ Gyrus fasciolaris
ā€¢ Continuation of dentate gyrus
ā€¢ Indusium griseum
ā€¢ Grey matter on upper surface of
corpus callosum
ā€¢ Contains 2 longitudinal bands
ā€¢ Medial & lateral longitudinal striae
ā€¢ Anteriorly ends in paraterminal
gyrus
ā€¢ Infront of lamina terminalis
Gyrus
fasciolaris
Indusium griseum
Paraterminal gyrus
Subiculam
ā€¢ Transitional zone
ā€¢ Between
ā€¢ Six layered
ā€¢ Entorhinal cortex and
ā€¢ Three layered
ā€¢ Hippocampus
Subcortical nuclei
ā€¢ Amygdaloid complex
ā€¢ Septal region
ā€¢ Olfactory areas
ā€¢ Hypothalamus
ā€¢ Anterior nucleus of
thalamus
Anterior nucleus of thalamus
Hypothalamus
Septal
Amygdaloid
Amygdala
ā€¢ Site
ā€¢ In temporal pole
ā€¢ Lies deep to uncus
ā€¢ Function
ā€¢ Fear
ā€¢ Emotions
ā€¢ Anger
ā€¢ Hormonal secretions
Paraterminal gyrus
ā€¢ Lies infront of lamina terminalis
ā€¢ 2 gyri
ā€¢ Para terminal gyrus
ā€¢ Parolfactory gyrus
ā€¢ Continues inferiorly
ā€¢ With diagonal band & medial olfactory
stria
ā€¢ Continues superiorly
ā€¢ With indusium griseum
Septal area
Pleasure zone
Piriform
ā€¢ 3 parts
ā€¢ Prepiriform region
ā€¢ Lateral olfactory gyrus
ā€¢ Gyrus ambiens
ā€¢ Gyrus seminularis
ā€¢ Entorhinal area
ā€¢ Uncus + parahippocampal gyrus
(anterior part)
Hypothalamus
ā€“ Lies
ā€“ Anteroinferior to thalamus
ā€¢ Mammilary bodies
ā€¢ Contains ANS nuclei
Thalamus
ā€¢ Anterior nucleus of thalamus
Fibres of limbic system
ā€¢ Stria terminalis
ā€¢ Fornix
ā€¢ Mamillo thalamic tract
ā€¢ Stria medullaris thalami
ā€¢ Cingulum
Stria terminalis
ā€¢ Begins in
ā€¢ Amygdaloid complex
ā€¢ Runs
ā€¢ Backwards in the roof of inferior
horn
ā€¢ Terminates near
ā€¢ Interventricular foramen
ā€¢ and anterior commissure by
dividing into various bundle
ā€¢ To
ā€¢ Hypothalamus & septal area
Amygdaloid body
Stria terminalis
Anterior commissure
Fornix
ā€¢ Formation
ā€“ Axons of hippocampus is called
alveus
ā€¢ Parts
ā€“ Fimbria (flat over dentate gyrus)
ā€“ Crus (when it becomes rounded)
ā€¢ Arches upwards & forwards underneath
splenium
ā€“ Body
ā€¢ Crura curving over thalamus converge
ā€¢ Lies beneath trunk of corpus of
callosum
ā€“ Column
ā€¢ Arches downwards towards anterior
commissure
ā€¢ Curves posteriorly to end in mamillary
body
ā€¢ Post commissural fornix
ā€¢ Precommissural fornix
C-shaped group of fibers
connecting
hippocampus with mammillary body
Mammillothalamic tract
ā€¢ Carry the impulses
ā€¢ From
ā€¢ Mammillary body
ā€¢ To
ā€¢ Anterior nucleus of thalamus
Mammillothalamic tract
Anterior nucleus of thalamus
Stria medullaris thalami
ā€¢ From
ā€¢ Septal area
ā€¢ To
ā€¢ Habenular nuclei
(amygdala and hippocampus)
Medial forebrain bundle
ā€¢ Consists of
ā€¢ Ascending & descending fibres of
hypothalamus
ā€¢ Ascending fibres
ā€¢ From midbrain
ā€¢ To hypothalamus
ā€¢ Descending fibres
ā€¢ From orbitofrontal cortex
ā€¢ Septal area, olfactory tubercle & piriform
cortex
ā€¢ To hypothalamus (lateral hypothalamic
zone & preoptic nuclei)
Cingulum
ā€¢ Connecting cingulate gyrus
to hippocampus
ā€¢ Association fibres
Applied anatomy
ā€¢ Korsakoffā€™s syndrome
ā€¢ Loss of recent memory
ā€¢ Results from deficiency of thiamine
(vitamin B1)
ā€¢ Leads to damage to mammillary bodies
and dorsomedial nucleus of thalamus
ā€¢ Temporal lobe epilepsy
ā€¢ Temporal lobe can be damaged
ā€¢ Through chronic seizures
ā€¢ Herpes encephalitis
ā€¢ Kluver-Bucy syndrome
ā€¢ Bilateral ablation of amygdaloid
ā€¢ Hyperphagia & hyper sex
Functions
ā€¢ Olfaction
ā€¢ Olfactory tract divides into lateral,
intermediate and medial stria
ā€¢ Lateral stria
ā€¢ Terminate in primary olfactory cortex of the
uncus
ā€¢ Some fibres
ā€¢ To hippocampal gyrus ā€“ Memory of smell
ā€¢ To amygdala ā€“ Emotion of smell
Functions ā€“ Memory / Learning
ā€¢ Papez circuit (James Papez, 1937)
ā€¢ Storing memory
ā€¢ Learning
Function ā€“ Emotions & behaviours
ā€¢ Emotion
ā€¢ Any stimulus produces fear, anger, rage
or sadness
ā€¢ Without conscious awareness
ā€¢ Due to increased activity in amygdala
Functions - Feeding
Reticular Nuclei
ā€¢ Location
ā€¢ Brainstem ā€“ Tegmentum
ā€¢ Arrangement
ā€¢ Three columns
ā€¢ Median column
ā€¢ Medial column
ā€¢ Lateral column
Median column
ā€¢ Lie
ā€¢ In mid line
ā€¢ From medulla to
midbrain
ā€¢ Nuclei
ā€¢ Nuclei of Raphe
Medial column
ā€¢ Lie
ā€¢ Lateral to nuclei of
median column
ā€¢ Nuclei
ā€¢ Neurons are large in size
ā€¢ So column can be named
as
ā€¢ Magnocellular column
ā€¢ Giganto cellular nucleus
ā€¢ Pontine tegmental
reticular nucleus
ā€¢ Cuneiform and sub
cuneiform nuclei
Lateral Column
ā€¢ Lie
ā€¢ Lateral to medial column
ā€¢ Nuclei
ā€¢ Made up of small cells
ā€¢ This column is known as
Parvocellular column
ā€¢ Control mainly the
visceral functions
Functional divisions
ā€¢ On the basis of functions
ā€¢ Two systems namely
ā€¢ Ascending reticular activating system
ā€¢ Descending reticular activating system
Ascending reticular activating system
ā€¢ Responsible for maintaining
ā€¢ Alertness & consciousness
ā€¢ Most of the ascending tracts
passing through brain stem
ā€¢ Gives collaterals to lateral part of
reticular formation
ā€¢ From lateral part of reticular formation
to intralaminar & reticular nuclei of
thalamus
ā€¢ From these nuclei fibres project to
cerebrum
Descending reticular system
ā€¢ Has
ā€¢ Descending pathways from reticular
formation to
ā€¢ Autonomic centres in brain stem
ā€¢ Lateral & anterior horns of spinal cord

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Limbic system anatomy

  • 1.
  • 2. Limbic system ā€¢ ā€œLimbicā€œ from Latin word Limbus ā€¢ Means "border" or "edge". ā€¢ Separates ā€¢ Medial surface of cerebral cortex ā€¢ From diencephalon ā€¢ Consists of ā€¢ Grey matter ā€¢ Cortical structures ā€¢ Subcortical structures ā€¢ White matter ā€¢ Interconnecting fibre tracts
  • 3. Grey matter ā€¢ Limbic lobe ā€¢ Hippocampal formation ā€¢ Amygdala ā€¢ Hypothalamus ā€¢ Thalamus ā€¢ Septal area ā€¢ Habenular nuclei (epithalamus)
  • 4. Limbic lobe ā€¢ C-shaped ring of grey matter ā€“ On medial surface of each cerebral hemisphere ā€¢ Surrounding the corpus callosum ā€“ 1. Subcallosal area ā€“ 2. Cingulate gyrus ā€“ 3. Isthmus ā€“ 4. Parahippocampal gyrus ā€“ 5. Uncus
  • 5. Subcallosal gyrus ā€¢ A narrow lamina of grey matter ā€¢ Lies ā€¢ Infront of lamina terminalis ā€¢ Behind the parolfactory area
  • 6. Cingulate gyrus ā€¢ Lies dorsal to ā€¢ Corpus callosum ā€¢ Receives inputs from ā€¢ Anterior nucleus of thalamus ā€¢ Projects to ā€¢ Entorhinal cortex via cingulum ā€¢ Involved with ā€¢ Emotion formation and processing, learning, and memory ā€¢ Lesions lead to ā€¢ Akinesia, mutism
  • 7. Parahippocampal gyrus Parahippocampus ā€¢ Lies in medial temporal lobe ā€¢ Medial to collateral sulcus ā€¢ Important role ā€¢ In memory encoding and retrieval ā€¢ ERC ā€¢ Funnels highly processed cortical information ā€¢ To hippocampal formation and serves as its major output pathway
  • 8. Uncus ā€¢ 2 parts by tail of dentate gyrus ā€¢ Uncinate gyrus ā€¢ Intralimbic gyrus
  • 9. Hippocampal formation Hippocampus Dentate gyrus Gyrus fasciolaris ā€¢ Hippocampus ā€¢ Dentate gyrus ā€¢ (Which lies medial to hippocampus) ā€¢ Gyrus fasciolaris ā€¢ Indusium griseum Cingulate gyrus Indusium griseum
  • 10. Hippocampus ā€¢ Consolidation of new memories ā€¢ Lies in ā€¢ Floor & medial wall of ā€¢ Inferior horn of lateral ventricle Called as cornu ammonis Ancient Egyptian deity, Ammon nferior horn of Lateral ventricle
  • 11. Hippocampus ā€¢ The most sensitive area in brain ā€¢ For Ischemic events in hippocampus is CA1 ā€¢ Trilaminate structure ā€¢ Molecular ā€¢ Pyramidal ā€¢ Polymorphic
  • 12. Dentate gyrus ā€¢ Longitudinal strip of grey matter ā€¢ Lies ā€¢ Medial to hippocampus ā€¢ Fused with hippocampus ā€¢ On its lateral margin ā€¢ Medial margin is crenated Dentate gyrus
  • 13. Dentate gyrus ā€¢ Anteriorly it ends as tail ā€¢ Runs across the inferior surface of uncus ā€¢ By that uncus is divided into ā€¢ Anterior uncinated gyrus ā€¢ Posterior intralimbic gyrus ā€¢ Posteriorly it continues as ā€¢ Gyrus fasciolaris
  • 14. Gyrus fasciolaris & Indusium griseum ā€¢ Gyrus fasciolaris ā€¢ Continuation of dentate gyrus ā€¢ Indusium griseum ā€¢ Grey matter on upper surface of corpus callosum ā€¢ Contains 2 longitudinal bands ā€¢ Medial & lateral longitudinal striae ā€¢ Anteriorly ends in paraterminal gyrus ā€¢ Infront of lamina terminalis Gyrus fasciolaris Indusium griseum Paraterminal gyrus
  • 15. Subiculam ā€¢ Transitional zone ā€¢ Between ā€¢ Six layered ā€¢ Entorhinal cortex and ā€¢ Three layered ā€¢ Hippocampus
  • 16. Subcortical nuclei ā€¢ Amygdaloid complex ā€¢ Septal region ā€¢ Olfactory areas ā€¢ Hypothalamus ā€¢ Anterior nucleus of thalamus Anterior nucleus of thalamus Hypothalamus Septal Amygdaloid
  • 17. Amygdala ā€¢ Site ā€¢ In temporal pole ā€¢ Lies deep to uncus ā€¢ Function ā€¢ Fear ā€¢ Emotions ā€¢ Anger ā€¢ Hormonal secretions
  • 18. Paraterminal gyrus ā€¢ Lies infront of lamina terminalis ā€¢ 2 gyri ā€¢ Para terminal gyrus ā€¢ Parolfactory gyrus ā€¢ Continues inferiorly ā€¢ With diagonal band & medial olfactory stria ā€¢ Continues superiorly ā€¢ With indusium griseum Septal area Pleasure zone
  • 19. Piriform ā€¢ 3 parts ā€¢ Prepiriform region ā€¢ Lateral olfactory gyrus ā€¢ Gyrus ambiens ā€¢ Gyrus seminularis ā€¢ Entorhinal area ā€¢ Uncus + parahippocampal gyrus (anterior part)
  • 20. Hypothalamus ā€“ Lies ā€“ Anteroinferior to thalamus ā€¢ Mammilary bodies ā€¢ Contains ANS nuclei
  • 22. Fibres of limbic system ā€¢ Stria terminalis ā€¢ Fornix ā€¢ Mamillo thalamic tract ā€¢ Stria medullaris thalami ā€¢ Cingulum
  • 23. Stria terminalis ā€¢ Begins in ā€¢ Amygdaloid complex ā€¢ Runs ā€¢ Backwards in the roof of inferior horn ā€¢ Terminates near ā€¢ Interventricular foramen ā€¢ and anterior commissure by dividing into various bundle ā€¢ To ā€¢ Hypothalamus & septal area Amygdaloid body Stria terminalis Anterior commissure
  • 24. Fornix ā€¢ Formation ā€“ Axons of hippocampus is called alveus ā€¢ Parts ā€“ Fimbria (flat over dentate gyrus) ā€“ Crus (when it becomes rounded) ā€¢ Arches upwards & forwards underneath splenium ā€“ Body ā€¢ Crura curving over thalamus converge ā€¢ Lies beneath trunk of corpus of callosum ā€“ Column ā€¢ Arches downwards towards anterior commissure ā€¢ Curves posteriorly to end in mamillary body ā€¢ Post commissural fornix ā€¢ Precommissural fornix C-shaped group of fibers connecting hippocampus with mammillary body
  • 25. Mammillothalamic tract ā€¢ Carry the impulses ā€¢ From ā€¢ Mammillary body ā€¢ To ā€¢ Anterior nucleus of thalamus Mammillothalamic tract Anterior nucleus of thalamus
  • 26. Stria medullaris thalami ā€¢ From ā€¢ Septal area ā€¢ To ā€¢ Habenular nuclei (amygdala and hippocampus)
  • 27. Medial forebrain bundle ā€¢ Consists of ā€¢ Ascending & descending fibres of hypothalamus ā€¢ Ascending fibres ā€¢ From midbrain ā€¢ To hypothalamus ā€¢ Descending fibres ā€¢ From orbitofrontal cortex ā€¢ Septal area, olfactory tubercle & piriform cortex ā€¢ To hypothalamus (lateral hypothalamic zone & preoptic nuclei)
  • 28. Cingulum ā€¢ Connecting cingulate gyrus to hippocampus ā€¢ Association fibres
  • 29. Applied anatomy ā€¢ Korsakoffā€™s syndrome ā€¢ Loss of recent memory ā€¢ Results from deficiency of thiamine (vitamin B1) ā€¢ Leads to damage to mammillary bodies and dorsomedial nucleus of thalamus ā€¢ Temporal lobe epilepsy ā€¢ Temporal lobe can be damaged ā€¢ Through chronic seizures ā€¢ Herpes encephalitis ā€¢ Kluver-Bucy syndrome ā€¢ Bilateral ablation of amygdaloid ā€¢ Hyperphagia & hyper sex
  • 30. Functions ā€¢ Olfaction ā€¢ Olfactory tract divides into lateral, intermediate and medial stria ā€¢ Lateral stria ā€¢ Terminate in primary olfactory cortex of the uncus ā€¢ Some fibres ā€¢ To hippocampal gyrus ā€“ Memory of smell ā€¢ To amygdala ā€“ Emotion of smell
  • 31.
  • 32. Functions ā€“ Memory / Learning ā€¢ Papez circuit (James Papez, 1937) ā€¢ Storing memory ā€¢ Learning
  • 33. Function ā€“ Emotions & behaviours ā€¢ Emotion ā€¢ Any stimulus produces fear, anger, rage or sadness ā€¢ Without conscious awareness ā€¢ Due to increased activity in amygdala
  • 35. Reticular Nuclei ā€¢ Location ā€¢ Brainstem ā€“ Tegmentum ā€¢ Arrangement ā€¢ Three columns ā€¢ Median column ā€¢ Medial column ā€¢ Lateral column
  • 36. Median column ā€¢ Lie ā€¢ In mid line ā€¢ From medulla to midbrain ā€¢ Nuclei ā€¢ Nuclei of Raphe
  • 37. Medial column ā€¢ Lie ā€¢ Lateral to nuclei of median column ā€¢ Nuclei ā€¢ Neurons are large in size ā€¢ So column can be named as ā€¢ Magnocellular column ā€¢ Giganto cellular nucleus ā€¢ Pontine tegmental reticular nucleus ā€¢ Cuneiform and sub cuneiform nuclei
  • 38. Lateral Column ā€¢ Lie ā€¢ Lateral to medial column ā€¢ Nuclei ā€¢ Made up of small cells ā€¢ This column is known as Parvocellular column ā€¢ Control mainly the visceral functions
  • 39. Functional divisions ā€¢ On the basis of functions ā€¢ Two systems namely ā€¢ Ascending reticular activating system ā€¢ Descending reticular activating system
  • 40. Ascending reticular activating system ā€¢ Responsible for maintaining ā€¢ Alertness & consciousness ā€¢ Most of the ascending tracts passing through brain stem ā€¢ Gives collaterals to lateral part of reticular formation ā€¢ From lateral part of reticular formation to intralaminar & reticular nuclei of thalamus ā€¢ From these nuclei fibres project to cerebrum
  • 41. Descending reticular system ā€¢ Has ā€¢ Descending pathways from reticular formation to ā€¢ Autonomic centres in brain stem ā€¢ Lateral & anterior horns of spinal cord