Dengue Virus - Dengue Hemorrhagic Fever list refrences used 1. How is the microorganism transmitted to the host? What is the preferred portal of entry? 2. How does the pathogen set up the initial infection? (adherence & invasion virulence factors) 3. What conditions are required for growth of the microbe? (anaerobic/aerobic -if appropriate intracellular/extracellular, tissue tropism, life cycle, etc) 4. How does the disease progress and how the virulence factors contribute to the progression? How does it damage host cells? 5. Give the specifics of how the pathogen evades the host immune defenses? 6. What symptoms and signs are usually present in the host? (prodromal, disease, convalescence) 7. How is the disease diagnosed? What treatments are effective against the microbe? How might the disease be prevented?.