Gluconeogenesis is the synthesis of glucose from non-carbohydrate precursors like lactate, pyruvate, amino acids, and glycerol. It mainly occurs in the liver and kidneys and is important for supplying glucose to tissues like the brain, red blood cells, and skeletal muscles during fasting when glucose from food is not available. The key steps in gluconeogenesis include the conversion of pyruvate to phosphoenolpyruvate and fructose-1,6-bisphosphate to fructose-6-phosphate to ultimately produce glucose from non-carbohydrate substrates.

2. Conti………….

3. GLUCONEOGENESIS
Contents to be discuss;
A Short Introduction
AND
Gluconeogenesis Pathway

4. INTRODUCTION
0 The synthesis of glucose from non-carbohydrate
precursors is known as gluconeogenesis.
0 major substrate/precursors - lactate, pyruvate,
glucogenic amino acids, propionate and glycerol.
0 Pathway generally occurs in cytosol, although some
precursors are produced in the mitochondria.
0 Gluconeogenesis mostly takes place in liver and
kidney.

5. IMPORTANCE OF
GLUCONEOGENESIS
0 Glucose is a central molecule for generating energy,
whenever required.
0 Brain, CNS, erythrocytes, testes and kidney are
dependent on continuous supply of energy for
performing normal functions.
0 Glucose is the only source that supplies energy to the
skeletal muscle, under anaerobic conditions.
0 In fasting, even more than a day gluconeogenesis
occurs to maintain the basic requirements of the body.

6. REACTIONS OF
GLUCONEOGENESIS
1. Conversion of Pyruvate to
Phosphoenol Pyruvate,
2. Conversion of fructose-1,6-
bisphophate to fructose-6-
phosphate,
3. Conversion of Glucose-6-
phosphate to Glucose,
---It involves glycolysis and KREB’S
cylce

8. Conti………