Iron metabolism & Disorder

1. SNEHITA PRASAD
LECTURER, Department of biochemistry
Narsinhbhai patel dental college & hospital

2. • Iron is one of the most essential trace element
• Total body iron content is 3 to 5 g.
• 75% present in blood, the rest is in liver, bone marrow & muscles.
• Iron is present in almost all cells.
• Heme is the most predominant iron-containing substance.
• It is a constituent of proteins/enzymes.

6. EXCRETION
STORAGE
TRANSPORT
ABSORPTION

10. Mechanism of iron
Absorption

12. Storage form
• Heme
• Ferritin
• Hemosiderin
Storage
site
Liver Intestine spleen
Bone
marrow

16. Iron excess
Iron deficiency

17. Treatment
Lab
Finding
Features
Causes
Reduction in the rate of hemoglobin synthesis and erythropoiesis.

20. Decreased hemoglobin
Hypochromic microcytic anemia
Decreased serum level
Decreased serum total ion binding
capacity
Decreased plasma ferritin