Abstract on Alzheimer's disease

1. SANSKAR COLLEGE OF PHARMACY AND REASERCH, NH-9,
Jindal Nagar, GHAZIABAD, INDIA
Alzheimer : Slow death
Sneha Pandey, Vipin Kumar, Anshika Sharma,Vishakha tyagi ,
Dr Shabnam Ain , Saurabh,Bhuvnesh Sharma,Aditya Tomar
Abstract
One of the most serious brain conditions affecting senior people is Alzheimer’s
disease. It is a significant cause of death and the most prevalent cause of
dementia in the elderly population. In terms of human suffering and economic
cost, Alzheimer’s disease imposes a significant burden on the entire world.
Amyloid plaques and neurofibrillary tangles are the pathological indicators of
Alzheimer’s disease . Language, personality, and cognitive control are all
impacted by the slow and progressive degradation of memory caused by all
these causes. Cerebrospinal fluid biomarkers are utilized in conjunction with
neuropsychological testing for the diagnosis of AD because not all cognitive skills
may be impacted. Cholinesterase inhibitors are the only medication used in
treatment currently that significantly improves symptoms in patients with AD’s
cognitive abilities. The degradation of brain tissue will continue for an AD carrier
even while they are receiving treatment. The development of new classes of
medications that target various neurotransmitter systems (cholinergic,
glutamatergic, etc.), both for the treatment of the cognitive deficit and the
treatment of the behavioral disturbances, as well as the development of
preventive methods (amyloid p-peptide immunisation), are some future
directions in the research and treatment of patients with Alzheimer’s disease.
Keyword: Alzheimer’s disease, Cholinesterase inhibitors, Amyloid plaques, beta-
secretase.