This document discusses genetics and late onset Alzheimer's disease. It notes that late onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's in older individuals. The Apolipoprotein E (APOE) gene, specifically the APOE*4 allele, is a major genetic risk factor for late onset Alzheimer's and accounts for about 30% of risk. However, the APOE*4 allele alone is not sufficient to cause Alzheimer's, suggesting other genetic or environmental factors also influence risk. Recent genome-wide studies have provided evidence of additional potential Alzheimer's risk genes on several chromosomes, with the strongest links found on chromosomes 12, 10, 9 and 6.

1. Genetics in late onset Alzheimer’s disease
Sneha Pandey, Vipin kumar, bhuvnesh sharma,Shabnam Ain, Qurratul Ain, Babita kumar
Sanskar college of pharmacy and research,
NH-24, Jindal Nagar, Ghaziabad, Uttar Pradesh
Corresponding author E-mail:
Abstract
Alzheimer’s disease (AD) is the most widely recognized type of dementia in the older and this complicated
problem is related with natural as well as hereditary parts. Late onset Alzheimer’s disease (LOAD,more
normal) are major recognized sorts of AD in eardly individuals. Late beginning Alzheimer’s disease (AD) is
a perplexing and multifactorial infection with the conceivable inclusion of a few qualities. Apolipoprotein
E (APOE), particularly the APOE*4 allele, has been laid out as areas of strength for a marker that records
for almost 30% of the gamble in late onset Alzheimer’s disease. Be that as it may, as the APOE*4 allele is
neither essential nor adequate for the improvement of AD, it underscores the contribution of other
hereditary or potentially ecological variables which, alone or related to APOE*4, can alter the gamble of
AD. As of late, genome wide linkage or linkage disequilibrium concentrates on late onset AD have given
educational information to the presence of numerous putative qualities for AD on a few chromosomes,
with the most grounded proof on chromosomes 12, 10, 9 and 6.
Key Words: Late Onset of Alzheimer’s disease, Apolipoprotein E (APOE), APOE*4 allele.