Alzheimer's disease biomarkers
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Alzheimer's disease (AD) is affecting aging populations worldwide at an alarming rate, with over 46.8 million cases estimated currently. As the population ages, this number is projected to increase substantially by 2050 unless effective interventions are developed and implemented. Efforts are needed to identify reliable biomarkers for early detection of AD. Proposed AD biomarkers include detecting pathophysiological processes in the brain using new imaging techniques and novel PET ligands, as well as measuring levels of hyperphosphorylated tau and low Aβ peptide in cerebrospinal fluid. New biomarkers are also being developed to detect various pathological processes like neuroinflammation, synaptic dysfunction, metabolic impairment, protein aggregation and neurodegeneration. Highly specific and sensitive blood biomarkers using
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Homeopathic system of medicine and there principle
This document provides an overview of homeopathy as a holistic medical system. It discusses the key principles of homeopathy, including using highly diluted substances that produce similar symptoms to treat illnesses. The document outlines different types of homeopathic remedies derived from plants, animals, minerals, and other sources. It also describes various administration methods and common uses to treat both acute and chronic conditions. Finally, the document summarizes the process for preparing homeopathic medicines through serial dilution and potentization.
Pharmacovigilance role and challenges phased by doctors
This document discusses adverse drug reactions (ADRs) in India's healthcare industry. It notes that ADRs are a major concern due to lack of regulation. It describes the different types of ADRs and their potential impacts on patients, doctors, and pharmaceutical companies. The document also outlines challenges faced by these groups and discusses legal remedies for patients harmed by ADRs. Finally, it stresses that preventing ADRs requires collaborative efforts through education, improved oversight, and enhanced reporting systems.
unit 4 Medicinal chemistry 5th semester notes.pdf
Unit 4 Medicinal chemistry notes
Important questions
drugs acting endocrine system
Sex hormones
Drugs of erectile dysfunction
Oral. Contraseptive
Corticosteroids
Thyroid and Anti thyroid
unit 2,pharmacology,chemical test for differentchemical constituents,5th seme...
Unit 2, pharmacology, chemical test for different chemical constituents.
5th semester
Chemical test of belladona, guggul, podophyllum, colophony, Myrrh, Resins, Benzoin, cardiac gylcoside, tannins, aloes chemical test, test for purine, saponin test, flavonoids chemical test, antraquinone chemical test, specific test for antraquinone glycosides test.
Isolation,extraction ,industrial production and uses of herbal plants unit 3n...
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
Metabolic pathway unit 1 pharmacology 5th semester
Shikmic acid cycle
Application and significance, definition
Mevalonic acid pathway, definition, application and significance.
Acetate malonate pathway, definition, application and significance
Amino-acid pathway, definition, application and significance
Modern methods of extraction unit 5 pharmacology
Pharmacology unit 5
5th semester
Chromatography (paper chromatography, HPLC, TLC, HPTLC)
Electrophoresis ( Paper electrophoresis, gel electrophoresis, capillary electrophoresis)
Spectroscopy (mass Spectroscopy,
Nuclear magnetic resonance spectroscopy, infrared spectroscopy, ultraviolet-visible spectroscopy)
"VITAMIN SUPPLEMENTS AND SCHIZOPHRENIA: UNRAVELING THE CONNECTION FOR IMPROVE...
Vitamin supplements such as vitamins B6, B12, folic acid, and choline may help reduce symptoms of schizophrenia by improving nutritional deficiencies, reducing oxidative stress, or modulating neurological pathways. The research suggests supplementing with these vitamins can decrease the occurrence and development of schizophrenia. Schizophrenia affects approximately 1% of the global population and onset is most common in late adolescence and early twenties. Deficiencies in folic acid and vitamin B6 may be a main cause of increased schizophrenia risk, particularly in countries with poor nutrition.
PARKINSON DISEASE -: Effects of Environmental and Pollution
Parkinson's disease is a brain disorder that causes shaking, stiffness, and difficulty with movement coordination. It is believed to be caused by both genetic and environmental factors. Mounting evidence shows that breathing polluted air increases the risk of developing Parkinson's, as pollutants and toxins can poison the nervous system and cause inflammation. This inflammation can increase the accumulation of a protein linked to Parkinson's and decrease neurons important for movement control. While some environmental exposures may lower Parkinson's risk, others like pesticides, solvents, metals, and other pollutants have been associated with an increased risk and can recreate Parkinson's pathology in animal models.
Climate change and neurodegenerative disease
Impact of changing climate on Neurodegenerative diseases like Alzheimer's disease , Parkinson's disease, dementia and motor neuron disease.
Environmental pollutants and Alzheimer's disease
Environmental pollutants like PM10, PM2.5, and acrolein can cross the blood-brain barrier and activate immune responses in the brain, making them neurotoxic and potentially increasing the risk of Alzheimer's disease. Studies have found correlations between exposure to air pollution and neurological disorders through mechanisms like oxidative stress, mitochondrial dysfunction, myelin sheath disruption, and blood-brain barrier alterations. This article examines the relationship between environmental factors and Alzheimer's disease, how pollution affects the human life stages and brain development, and the link to various neurological disorders.
Late onset Alzheimer's disease
This document discusses genetics and late onset Alzheimer's disease. It notes that late onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's in older individuals. The Apolipoprotein E (APOE) gene, specifically the APOE*4 allele, is a major genetic risk factor for late onset Alzheimer's and accounts for about 30% of risk. However, the APOE*4 allele alone is not sufficient to cause Alzheimer's, suggesting other genetic or environmental factors also influence risk. Recent genome-wide studies have provided evidence of additional potential Alzheimer's risk genes on several chromosomes, with the strongest links found on chromosomes 12, 10, 9 and 6.
Genetics of Early onset Alzheimer's disease.docx
This document summarizes genetics research on early onset Alzheimer's disease (EOAD). It notes that EOAD cases are inherited in an autosomal dominant pattern, with dominant mutations in genes like amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) linked to Alzheimer's. Identifying new Alzheimer's-related genes is important for better understanding the pathomechanisms leading to neurodegeneration. Genetic testing is also crucial for diagnostic processes since differential diagnoses of neurodegenerative diseases can be difficult, especially in early stages.
Parkinson's disease biomarkers.docx
The document discusses potential biomarkers for Parkinson's disease (PD). It notes that PD is caused by a lack of dopamine in the brain resulting from the death of dopaminergic cells. While studies are ongoing, there is still no cure for PD. The document examines different types of biomarkers that could help distinguish PD from other conditions and monitor its progression, including clinical, imaging, biochemical, and genetic biomarkers. It highlights that various forms of α-synuclein protein and dopamine metabolites in cerebrospinal fluid and blood have shown promise as biomarkers. MicroRNA analysis combined with α-synuclein data may also provide insights. Metabolomics analysis could uncover metabolic fingerprints specific to different PD stages. The review focuses on developing
soybean isoflavone in treatment of Alzheimer's disease 1.docx
Soybean isoflavone (SIF) shows potential for treating Alzheimer's disease. SIF has a similar chemical structure to estrogen and strong antioxidant properties. It inhibits amyloid beta aggregation and reduces inflammation in the brain, which are pathological features of Alzheimer's disease. SIF intake may help prevent or delay Alzheimer's disease progression by these mechanisms. Further research is needed to establish SIF as an effective treatment for Alzheimer's disease.
epilepsy.docx
Epilepsy is a neurological disorder that affects millions of people in the United States and around the world. It causes abnormal signals in clusters of brain neurons that can lead to seizures. While anti-epileptic drugs can help control seizures for many, epilepsy has no cure and our understanding of its exact pathophysiology remains incomplete. The document discusses epilepsy's definition, diagnosis, related clinical disorders, treatment options, and areas that require further research to improve treatment.
Legumes Report-12.docx
The document discusses research that has been done on legumes in several areas:
- Domestication and breeding to develop more productive and resistant varieties
- Nutrition research to understand their health benefits and use in improving human health
- Agronomy research on efficient and sustainable growing methods
- Food processing research to make legumes more versatile ingredients
It also summarizes pharmacological research showing legumes contain compounds that may help treat cancer, diabetes, heart disease and inflammation. Recent studies have investigated specific compounds and legume health benefits. Scientists are developing more resistant crop varieties to increase global supply and nutrition.
blood based biomarkers sneha.docx
Blood-based biomarkers for Alzheimer's disease have long seemed out of reach, but recent studies have consistently shown that amyloid and phosphorylated tau proteins in blood correlate with concentrations in cerebrospinal fluid and positron emission tomography scans, indicating blood tests could become a reality. Additional blood markers of neurodegeneration like neurofilament light chain and glial fibrillary acidic protein also provide information on disease progression and potential for monitoring treatment effects. The question now is when and how these biomarkers can be brought into clinical practice.
ALZHEIMER'S DISEASE poster
Alzheimer's disease is characterized by the abnormal build-up of amyloid and tau proteins in the brain, which is believed to cause neuronal death and loss of brain function. Symptoms appear as brain cells become affected and include memory loss, cognitive decline, and issues with language and visuospatial abilities. While there is no cure for Alzheimer's, some drugs can temporarily reduce symptoms by targeting amyloid plaques or preserving acetylcholine levels. The strongest genetic risk factor is an APOE allele. Recent treatments focus on reducing amyloid production and preventing tau hyperphosphorylation to improve neuronal connectivity and function.
More from Sneha Pandey (20)
homeopathy system of medicine herbal drug technology
homeopathy system of medicine herbal drug technology
Homeopathic system of medicine and there principle
Homeopathic system of medicine and there principle
Pharmacovigilance role and challenges phased by doctors
Pharmacovigilance role and challenges phased by doctors
unit 2,pharmacology,chemical test for differentchemical constituents,5th seme...
unit 2,pharmacology,chemical test for differentchemical constituents,5th seme...
Isolation,extraction ,industrial production and uses of herbal plants unit 3n...
Isolation,extraction ,industrial production and uses of herbal plants unit 3n...
Metabolic pathway unit 1 pharmacology 5th semester
Metabolic pathway unit 1 pharmacology 5th semester
"VITAMIN SUPPLEMENTS AND SCHIZOPHRENIA: UNRAVELING THE CONNECTION FOR IMPROVE...
"VITAMIN SUPPLEMENTS AND SCHIZOPHRENIA: UNRAVELING THE CONNECTION FOR IMPROVE...
PARKINSON DISEASE -: Effects of Environmental and Pollution
PARKINSON DISEASE -: Effects of Environmental and Pollution
soybean isoflavone in treatment of Alzheimer's disease 1.docx
soybean isoflavone in treatment of Alzheimer's disease 1.docx
Recently uploaded
A Strategic Approach: GenAI in Education
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
DRUGS AND ITS classification slide share
Any substance (other than food) that is used to prevent, diagnose, treat, or relieve symptoms of a
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ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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The History of Stoke Newington Street Names
Presented at the Stoke Newington Literary Festival on 9th June 2024
www.StokeNewingtonHistory.com
Digital Artifact 1 - 10VCD Environments Unit
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South African Journal of Science: Writing with integrity workshop (2024)
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A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
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আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
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Thinking of getting a dog? Be aware that breeds like Pit Bulls, Rottweilers, and German Shepherds can be loyal and dangerous. Proper training and socialization are crucial to preventing aggressive behaviors. Ensure safety by understanding their needs and always supervising interactions. Stay safe, and enjoy your furry friends!
The simplified electron and muon model, Oscillating Spacetime: The Foundation...
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
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Alzheimer's disease biomarkers
- 1. ALZHEIMER DISEASES (AD): BIOMARKERS *Bhuvnesh Sharma, Shabnam Ain, Qurratul Ain, Sneha Pandey and Vipin Kumar Corresponding author: bhuvnesh Sharma Sanskar College of Pharmacy and Research Ghaziabad Nh-9 opp Jindal pipes Uttar Pradesh Abstract Alzheimer’s sickness (Promotion) and related dementias are influencing the maturing populace all through the world, at a disturbing rate. World Alzheimer’s Report demonstrates a predominance of 46.8 million impacted with Promotion around the world. As populace ages, this number is projected to significantly increase by 2050 except if compelling intercessions can be created and executed. Dire endeavors are expected for an early discovery of this infection. A definitive objective is the distinguishing proof of reasonable focuses for the advancement of sub-atomic markers and approval of their utilization for early conclusion of Promotion that might further develop treatment and the sickness result in patients. The analysis of Promotion has been hard to determine since approaches for right on time and precise recognition and follow-up of Advertisement patients at the clinical level have been accounted for as of late. Proposed Promotion biomarkers incorporate location of pathophysiological processes in the mind in vivo with new imaging procedures and novel PET ligands, and assurance of pathogenic proteins in cerebrospinal liquid appearance peculiar degrees of hyperphosphorylated tau and low Aβ peptide. These biomarkers have been progressively acknowledged by Promotion symptomatic rules and are significant devices for the plan of clinical preliminaries, however troubles in availability to exorbitant and obtrusive methods isn’t completely tackled in clinical settings. New biomarkers are right now being created to permit conclusions of various obsessive cycles including neuroinflammation, synaptic brokenness, metabolic weakness, protein collection and neurodegeneration. Profoundly unambiguous and delicate blood biomarkers, utilizing less-obtrusive strategies to distinguish Promotion, gets from the revelations of peripheric tau oligomers and amyloid variations in human plasma and platelets. We have likewise fostered a blood tau biomarker that connects with mental degradation and furthermore with neuroimaging judgments of cerebrum decay. KEY Words: Alzheimer, Tau, Biomarkers, PET.