1. Genetic Alzheimer : The Curse Disease
Sneha Pandey, Vipin Kumar, Shabnam Ain and Qurratul Ain, Bhuvnesh sharma,
Saurabh
Corresponding Author: Sneha Pandey, E-mail: sneha21-bpharm@sanskar.org
Abstract
Alzheimer's disease causes a great deal of suffering for people worldwide and costs a lot of money.
It is the most prevalent cause of dementia and a complex, heterogeneous neurodegenerative
disorder. Familial Alzheimer’s disease (FAD), another name for genetic Alzheimer’s disease
(GAD), is an uncommon type of the disease with a significant genetic component. Particular gene
mutations, including those in APP, PSEN1, and PSEN2, are linked to its development. Genetic
Alzheimer’s frequently appears earlier in life, usually between the ages of 30 and 60, in contrast
to sporadic Alzheimer’s, which develops later in life. Only a small portion of cases of Alzheimer’s
are of this form; most cases are sporadic. These mutated genes are more likely to be inherited by
people who have a family history of early-onset Alzheimer’s disease. Genetic mutations cause the
brain to produce too much or accumulate too much beta-amyloid protein, which builds up in
plaques that obstruct neuronal communication and cause neurodegeneration. Genetics
significantly contributes to 70% of Alzheimer's disease risk, with the Λ-4 allele of the APOE gene
being a major risk factor. Signs of inherited Similar to the more prevalent type of the illness,
Alzheimer’s causes memory loss, cognitive decline, and behavioural abnormalities. In genetic
cases, the symptoms tend to progress more quickly, leading to a faster decline in cognitive
function. In order to create tailored treatments, research is being done to comprehend the molecular
mechanisms underlying genetic Alzheimer’s disease. Individuals who are at risk can be identified
through genetic testing, which opens the door to early intervention and possible clinical trial
participation. The difficulty of treating this type of Alzheimer’s disease is highlighted by ethical
issues and the lack of a treatment.
Key Words : Genetic Alzheimer, FAD, PSEN1, PSEN2 ,
