Genetics of Alzheimer's disease

1. Genetics of early onset Alzheimer’s disease
*Yash kumar , Shabnam Ain, Qurratul Ain, Sneha Pandey, Kirti Singh Tomar
Sanskar college of Pharmacy and research , NH-24, Jindal Nagar, Ghaziabad, Uttar Pradesh
Corresponding author E-mail- 11kumaryash@gmail.com
Abstract
Alzheimer’s disease (AD) is a problem that causes degeneration of the cells in the mind and it is the primary driver of dementia,
which is portrayed by a decrease in thinking and freedom in private everyday exercises. Etiology of the sickness isn’t know yet
hereditary elements assume a significant part in deciding individual’s dangers for growing Promotion. Early onset Alzheimer’s
disease (EOAD) cases are acquired in an autosomal predominant example. Here, predominant transformations in qualities like
amyloid Precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) related with Alzheimer’s disease. Recognizable
proof of new AD related qualities is significant for better comprehension of the pathomechanisms prompting
neurodegeneration. Since the differential findings of neurodegenerative problems are troublesome, particularly in the beginning
phases, hereditary testing is fundamental for symptomatic cycles. Cutting edge sequencing studies have been effectively utilized
for recognizing transformations, observing the epigenetic changes, and investigating transcriptomes. These examinations might
be a promising methodology toward understanding the total hereditary systems of different hereditary problems like
Alzheimer’s.
Key words: Early onset Alzheimer’s disease (EOAD), amyloid precursor, presenilin 1, presenilin 2 .