Good

1. Metabolism Electron Transport Chain
2 NADH
2 NADH
2 NADH
2 NAD+
2 NAD+
2 NAD+
2 NADH
2 NAD+
2 NADH
2 NAD+ 2 FADH
2 FAD
Mitochondrial Matrix
Glucose
(2) Pyruvate
Pyruvate
Acetyl
CoA
NADH
NAD+
FMN
FMNH
Q
QH
FADH FAD
FMN
FMNH
Q
QH
NADH D.H. (CoQ )
Succinate D.H.
H+
(CoQ )
Q-Cyt-
Oxidoreductase
Cyt
F
F
+3
+2
[H+] = 10 mM
[H+] = 10 mM
H+
Cyt-c
Cyt-c
F
F
+3
+2
Cytochrome Oxidase
Cyt ( + )
3
F +3
F +2
2 H+
H O
H+
(F S)
[H+] = 10 mM
NADH
NAD+
Malate
OAA
M.D.H
Malate
Malate
Malate
2 NADH
2 NAD+
NADH
OAA
OAA Glutamate (A.A.)
Aspartate
Aspartate
- Keto Gluterate
- Keto Gluterate
Aspartate
Glutamate
OAA
M.D.H+
Malate
Aspartate
Shuttle
NADH NAD+
Glycerol-3-P DHAP
Glycerol-3-P
Shuttle
FAD
FADH
DHAP
Fatty-Acyl-CoA
FAD
FADH
Enoyl-CoA
Acyl CoA D.H. +
Glycerol-3-p D.H.+
FADH
B-oxidation
ETC TALLY
Glycolysis:
Transition:
Krebs:
C
F
F
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ +
+
+
H
+
H
Arg-210
Rotor
Rod
ADP
Pi
ATP
Chemiosmosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
ATP
2,4 D.N.P
((HEAT))
CN-
-
Histoxic Hypoxia
CO
-
Thermogenin
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
ATP
HEAT
+
Oligomycin
-
-
Aurovertin
2 ATP (S.P)=2 ATP
2 NADH=6 ATP
2 NADH=6 ATP
2 NADH=18 ATP
2 FADH=4 ATP
2 ATP (S.P)=2 ATP
38 ATP
Electron Transport Chain
METABOLISM:
-
9
b
→
• • • • • • b
i
'
• • •
-9 A A
z z
• . . . . .
"
.%•↳
• • • • • •
• • • • •
• • •
•
• •
• • • • •
• • • •
→%⑧,
• • • •
• • • •
•••
A
÷
,