B. Pharmacy Second year, third semester

1. By- S. K. Dhawale
Assistant Professor
D. K. Patil Institute of pharmacy

2.  Pharmaceutical plant need to be constructed of
materials to have strength, non reactivity, corrosion
resistance and suitable as per FDA and GDP norms.
Factors influencing selection of materials of construction
Chemical factors – contamination of product
Corrosion of material of construction
Physical factors – strength, wear properties, thermal
expansion, cleaning.
Economic factors – mass, thermal conductivity, Ease of
fabrication, sterilisation, transparency.
DKPIOP 2

3. A) Metals:
a) Ferrous metals- cast iron, stainless steel, steel carbon.
b) Non-ferrous – Aluminium, lead.
B) Non – metals:
a) Inorganic- glass
b) organic- rubber, plastic.
DKPIOP 3

4.  Corrosion it is a natural process, which converts a
metal to more chemically – stable form, such as oxides,
hydroxide, or sulfide.
 It is a gradual destruction of materials by chemical and
electrochemical reaction with their environment.
 Corrosion can be define as reaction of metallic
materials with its environments which causes
undesirable changes in materials and can result in a
functional failure of the metel.
 Corrosion degrads the properties of materials and
structure including strsngth appearance, and
permeability to liquid and gas.
4
DKPIOP

5.  The metal surface undergoes an electrochemical
reaction with the moisture and oxygen in the
atmosphere, this theory is called as electrochemical
theory of corrosion.
 The mechanism involves the formation of galvanic cell
( anodic and cathodic areas), by different metals or in
differentareas on same piece of metal.
Corrosive reaction of metals is electrochemical in nature,
when a metal corrodes an anod and a cathode form a
cell in conjugation with an electrically conducting
enviornment.
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DKPIOP

6.  Single metal corrosion
 Corrosion between metals
 Concentration cell corrosion
 Pitting corrosion
 Intergranular corrosion
 Parting or dezincification
 Stress corrosion
 Erosion corrosion
Corrosion control methods
a)By changing metals
b)Altering environment c)by separating metal from
environment
d)By changing electrode potential of the metal e) use of
coating
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DKPIOP

7.  Rate and extent of corrosion depends on following
factors
 Nature of the metals
 Position in galvanic series
 Relative areas of the anodic and cathodic parts
 Purity of metals
 Physical state of metals
 Nature of surface film
 Solubility of corrosion product
 Volatility of corrosion products
DKPIOP 7

8. 1) Handling of solids
conveyors:
pharmaceutical Belt conveyor
Flexible conveyor
Line shaft conveyor
heavy duty roller conveyor
Vertical conveyor
spiral conveyor
sortation conveyor
2) Handling of Liquids
Pipes, valves, Pumping and Compression, and
Reciprocating pumps DKPIOP 8

9. DKPIOP 9