This presentation gives a little details about 5th generation of cephalosporins and their usage. it was done as a university presentation for Microbiology class.

1. 5TH GENERATION
CEPHALOSPORINS
Dr. Peymani
Sara Bakhshi
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2. Contents
• What are Cephalosporins
• History of Cephalosporins
• Mechanism of action
• Generation of Cephalosporins
• 5th generation of Cephalosporins
– Ceftobiprole
– Ceftaroline
– Ceftolozane
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3. What are
Cephalosporins
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4. • A class of β-lactam antibiotics originally derived from
the fungus Acremonium, which was previously
known as "Cephalosporium".
• Inhibit wide variety of gram(+) and gram(-) bacteria.
Sara Bakhshi
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5. History of
cephalosporins
• Cephalosporium acremonium
from a sewer in Sardinia in 1945 by
Italian scientist Giuseppe Brotzu.
• Were first sold in 1964
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6. Core
structure
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7. Mechanism of
action
• Disrupt the synthesis of the
peptidoglycan layer forming the
bacterial cell wall.
• Beta-lactam antibiotics mimic the
D-Ala-D-Ala site, thereby
irreversibly inhibiting PBP
crosslinking of peptidoglycan.
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8. Generation of
Cephalosporins
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9. 5th generation
of
Cephalosporins
• developed in the lab to specifically
target against resistant strains of
bacteria.
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10. Members of
5th Generation
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•Ceftobiprole
•Ceftaroline
•Ceftolozane
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11. Ceftobiprole
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• Ceftobiprole is effective against methicillin-
resistant Staphylococcus aureus (MRSA)
• for the treatment of hospital-acquired
pneumonia (HAP), excluding ventilator-
associated pneumonia (VAP), and community-
acquired pneumonia (CAP)
• It is mainly excreted renally.

12. Ceftobiprole
structure
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13. Ceftaroline • With activity against aerobic and
anaerobic gram(+) and aerobic gram(-)
bacteria .
• Associated with skin and respiratory
infections.
• Also has activity against methicillin-
resistant Staphylococcus aureus and
Streptococcus pneumonia.
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14. Ceftaroline
structure
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15. • FDA has approved Ceftaroline
Fosamil under the trade name
Teflaro.
• Indicated for the treatment of
adults with acute bacterial skin
and skin structure infections
(ABSSSI)
• Also for the treatment of
community-acquied bacterial
pneumonia (CABP)
 Caused by susceptible Gram+ and Gram- microorganisms, such as
Staphylococcus aureus (including methicillin-susceptible and -resistant isolates),
Streptococcus pyogenes Streptococcus agalactiae, E-coli, Klebsiella pneumoniae ,
and Klebsiella oxytoca.
 Caused by susceptible Gram+ and Gram- bacteria, such as Streptococcus
pneumoniae (including cases with concurrent bacteremia), Staphylococcus
aureus (methicillin-susceptible isolates only), Haemophilus influenzae ,
Klebsiella pneumoniae , Klebsiella oxytoca , and E-coli.
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16. Ceftolozane
(Zerbaxa)
• Anew option for treatment of
Complicated Intra-abdominal
Infections (cIAI), and Complicated
Urinary Tract Infections (cUTI).
• Is combined with the β-lactamase
inhibitor tazobactam, as multi-
drug resistant bacterial infections
will generally show resistance to
all β-lactam antibiotics unless this
enzyme is inhibited.
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17. Ceftolozane
structure
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18. Thanks For Your Attention
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