The impact of evidence- based research and mentorship as effective response to future epidemics and disruptions in any sector of the world’s economy, including educational sector have been remarkable. Research and Mentorship seek to identify knowledge gaps in education and motivate individuals to effectively handle those deficiencies. In the last triennial, research and mentorship have grown in importance as it seeks to build students and institution’s confidence, improves communication, critical thinking and problem- solving skills and helps us to better understand the evolving educational needs. In Ghana, the Ministry of Education through evidence- based research strategies is enhancing continuity of safe and inclusive schools by building new STEAM schools and providing good water. Nevertheless, the issue of inconsistent methodological practices and varied definitions for the same topic coupled with the risk of being bias, time consuming and cost- involving makes it difficult to quantify its influence on individuals, institutions and communities. This paper therefore seeks to understand the role of research and mentorship in promoting sustainable quality education in Africa