The impact of research and mentorship in a fast- paced digitized world on institutions of higher education, communities and nations have been remarkable. Evidence- based research and mentorship have been associated with enhanced science identity, productivity, recruitment and career satisfaction and self- efficacy of individuals and institutions and helps us to better understand the evolving community needs. In the last quinquennial, research and mentorship have grown in importance as it seeks to build individual’s and institution’s confidence, improves communication, critical thinking and problem- solving skills. However, the issue of inadequate documentation, inconsistent methodological practices, varied definitions for the same topic coupled with the risk of being bias, time consuming and cost- involving makes it difficult to quantify its influence on individuals, institutions and communities. The study therefore examines the effectiveness of research and mentorship on the performance of students and faculty members in institutions of higher education in Ghana.