This document summarizes the Traube purine synthesis reaction. The Traube synthesis allows for the introduction of a carbon fragment to bridge the nitrogen atoms of the amino group at positions C-5 and C-6 of a pyrimidine ring. It involves the formylation of 4,5-diaminopyrimidine followed by cyclodehydration to produce a purine. 4,5-Diaminopyrimidine is synthesized from 4-aminopyrimidine using formic acid or its derivatives. The mechanism involves the initial formation of an iminium ion intermediate followed by ring closure. Adenine can be synthesized using this reaction by reacting 6-chloro-4,5-di

1. Guided By:
Prof Ms. Jayshree R Jagtap
Advanced Organic Chemistry
PUNE DISTRICT EDUCATION ASSOCIATION’S
Seth Govind Raghunath Sable Pharmacy College, Saswad, Pune
Presented by:
Mr. Pratik Sunil Kapase
First year M.Pharm
(Pharmaceutical Chemistry)
6/16/2023

2. CONTENTS
LEARNING OBJECTIVE
INTRODUCTION
BASIC REACTION
MECHANISM OF REACTION
CONCLUSION
REFERENCES
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3. LEARNING OBJECTIVE
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• To know about traube synthesis
• To know the mechanism involve in traube purine synthesis
• To learn application of traube purine synthesis

4. • This reaction was 1st introduced by taube in 1900
• Traube purine synthesis is the most versatile method for introduction of carbon
fragment to bridge the nitrogen from atoms of the amino group C-5 and C-6 of
pyrimidine ring .
• The pyrimidines of high purity as starting materials should be used for this reaction.
INTRODUCTION
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5. Basic reaction
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It is the most widely used for the synthesis of purine. 4,5-Diaminopyrimidine on formylation
followed by cyclodehydration provide purine. 4,5-Diaminopyrimidine is synthesised from 4-
aminopyrimidine other formic acid derivatives like formamide, formamidine , orthoformic esters
etc.

6. Mechanism of Taube purine synthesis
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7. Synthetic application
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Adenine can be prepare by the interaction of 6-chloro-4,5-diamonopyridine with diethoxy
methyl acetate to furnish 6-Chloropurine which on subsequent which on subsequent
animation with ammonia yield the desired product.

8. 6/16/2023
The procedure involve the reaction of 4-amino-5 –nitrosopyrimidine with formic acid in the
presence of Raney nickel to afford purine. This regarded as a convenient route for the purine
synthesis
Synthetic application

9. Conclusion
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The Traube purine synthesis is 4,5-Diaminopyrimidine on formylation followed by
cyclodehydration provide purine. 4,5-Diaminopyrimidine is synthesised from 4-
aminopyrimidine. this reaction may undergo only the formylation at the 5‐amino group without
further cyclization

10. References
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1. Arun R Parikh ,Hasna Parikh, Ranjan Khut ,The essence of heterocyclic chemistry , Fourth eddion
New age International Publication ,Page no 616-617
2. J.A.Joule and K.Mills, Heterocyclic Chemistry, Willey Publication, Fifth edition ,Page no 531-534
3.https://Scholer.google.com

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