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TRAUBE PURINE SYNTHESIS.pptx
1. Guided By:
Prof Ms. Jayshree R Jagtap
Advanced Organic Chemistry
PUNE DISTRICT EDUCATION ASSOCIATION’S
Seth Govind Raghunath Sable Pharmacy College, Saswad, Pune
Presented by:
Mr. Pratik Sunil Kapase
First year M.Pharm
(Pharmaceutical Chemistry)
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3. LEARNING OBJECTIVE
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• To know about traube synthesis
• To know the mechanism involve in traube purine synthesis
• To learn application of traube purine synthesis
4. • This reaction was 1st introduced by taube in 1900
• Traube purine synthesis is the most versatile method for introduction of carbon
fragment to bridge the nitrogen from atoms of the amino group C-5 and C-6 of
pyrimidine ring .
• The pyrimidines of high purity as starting materials should be used for this reaction.
INTRODUCTION
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5. Basic reaction
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It is the most widely used for the synthesis of purine. 4,5-Diaminopyrimidine on formylation
followed by cyclodehydration provide purine. 4,5-Diaminopyrimidine is synthesised from 4-
aminopyrimidine other formic acid derivatives like formamide, formamidine , orthoformic esters
etc.
7. Synthetic application
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Adenine can be prepare by the interaction of 6-chloro-4,5-diamonopyridine with diethoxy
methyl acetate to furnish 6-Chloropurine which on subsequent which on subsequent
animation with ammonia yield the desired product.
8. 6/16/2023
The procedure involve the reaction of 4-amino-5 –nitrosopyrimidine with formic acid in the
presence of Raney nickel to afford purine. This regarded as a convenient route for the purine
synthesis
Synthetic application
9. Conclusion
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The Traube purine synthesis is 4,5-Diaminopyrimidine on formylation followed by
cyclodehydration provide purine. 4,5-Diaminopyrimidine is synthesised from 4-
aminopyrimidine. this reaction may undergo only the formylation at the 5‐amino group without
further cyclization
10. References
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1. Arun R Parikh ,Hasna Parikh, Ranjan Khut ,The essence of heterocyclic chemistry , Fourth eddion
New age International Publication ,Page no 616-617
2. J.A.Joule and K.Mills, Heterocyclic Chemistry, Willey Publication, Fifth edition ,Page no 531-534
3.https://Scholer.google.com