SlideShare a Scribd company logo
Mathematical Modeling of Mass and Heat Transfer to Determine Softgel Drying Rates
C. Spiegel, D. Fulper
Catalent Pharma Solutions
Purpose
The purpose of this study was to create a transient mass and heat transfer model to predict softgel drying rates in order to
improve and optimize existing drying processes. The mass and heat transfer model determines the temperatures and the water
concentrations in and on the surface of the gelatin film in order to understand the potential impact of changing humidity and
air velocities on final capsule water activity, brittleness, and fill moisture.
Methods
A Matlab-based program was developed to analyze the mass and temperature distribution in a gelatin film with temperature,
humidity, and air velocity with varying ribbon thickness. The total ribbon/softgel volume is divided into nodes in order to
accurately calculate the drying rates. The mass and energy balances for each node are integrated simultaneously using
MATLAB’s ode45 function. Arrays were created for the node water concentration, temperatures, heat flows, and thermal
conductivities of each node. Fick's law is used to model the diffusion in each node. Depending upon the air velocity, either
Ficks's law or convective mass transfer equations are used to model the mass transfer of water from the gelatin surface into
the surrounding air.
Results
The results of the model showed that optimal drying of gelatin temperature is a balance between low relative humidities and
low air velocities. Increased humidity (> 50%) does not allow the softgel to dry properly because the softgel shell obtains an
equilibrium between the shell and the surrounding environment. Increased temperatures and velocities aid in the drying
process to a certain extent, however, high velocities and temperatures are not effective due to "case hardening". The drying
process can be optimized for each gelatin and fill formulation.
Conclusion
Simulation of gelatin drying processes can provide insight into the transport phenomena that is occurring in order to avoid
costly and time-consuming experimentation. It can be used to determine optimal states of humidity, air velocity, and
temperature for drying gelatin. These drying conditions determine the final percent moisture in the fill material and shell
material, which in turn determines final capsule hardness, brittleness and quality.

More Related Content

What's hot

LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
YASMINE HASLAN
 
What is mass transfer?
What is mass transfer?What is mass transfer?
Mass transfer
Mass transferMass transfer
Mass transfer
Riadh Al-Haidari
 
Volume and Density for secondary students
Volume and Density for secondary studentsVolume and Density for secondary students
Volume and Density for secondary students
LalitKishore18
 
18th january presentation
18th january presentation18th january presentation
18th january presentation
Taha Sochi
 
Industrial pharmacy complete notes
Industrial pharmacy complete notesIndustrial pharmacy complete notes
Industrial pharmacy complete notes
Ghulam Murtaza Hamad
 
Liquid Limit of soil sample
Liquid Limit of soil sampleLiquid Limit of soil sample
Liquid Limit of soil sample
MuhammadEhtishamArsh
 
On the coupling between Dissipartive Particle Dynamics and Computational Flui...
On the coupling between Dissipartive Particle Dynamics and Computational Flui...On the coupling between Dissipartive Particle Dynamics and Computational Flui...
On the coupling between Dissipartive Particle Dynamics and Computational Flui...
Hermes Droghetti
 
Flow and heat transfer in rectangular microchannels, Scholars Press.com
Flow and heat transfer in rectangular microchannels, Scholars Press.comFlow and heat transfer in rectangular microchannels, Scholars Press.com
Flow and heat transfer in rectangular microchannels, Scholars Press.com
Mirmanto
 
Units and variables
Units and variablesUnits and variables
Units and variables
Kati Jordan
 
Investigations in Effective Viscosity of Fluid in a Porous Medium
Investigations in Effective Viscosity of Fluid in a Porous MediumInvestigations in Effective Viscosity of Fluid in a Porous Medium
Investigations in Effective Viscosity of Fluid in a Porous Medium
IJERA Editor
 
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
International Journal of Science and Research (IJSR)
 

What's hot (12)

LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
LAB REPORT HYDRAULIC EXP 1 : PROPERTIES OF FLUID.
 
What is mass transfer?
What is mass transfer?What is mass transfer?
What is mass transfer?
 
Mass transfer
Mass transferMass transfer
Mass transfer
 
Volume and Density for secondary students
Volume and Density for secondary studentsVolume and Density for secondary students
Volume and Density for secondary students
 
18th january presentation
18th january presentation18th january presentation
18th january presentation
 
Industrial pharmacy complete notes
Industrial pharmacy complete notesIndustrial pharmacy complete notes
Industrial pharmacy complete notes
 
Liquid Limit of soil sample
Liquid Limit of soil sampleLiquid Limit of soil sample
Liquid Limit of soil sample
 
On the coupling between Dissipartive Particle Dynamics and Computational Flui...
On the coupling between Dissipartive Particle Dynamics and Computational Flui...On the coupling between Dissipartive Particle Dynamics and Computational Flui...
On the coupling between Dissipartive Particle Dynamics and Computational Flui...
 
Flow and heat transfer in rectangular microchannels, Scholars Press.com
Flow and heat transfer in rectangular microchannels, Scholars Press.comFlow and heat transfer in rectangular microchannels, Scholars Press.com
Flow and heat transfer in rectangular microchannels, Scholars Press.com
 
Units and variables
Units and variablesUnits and variables
Units and variables
 
Investigations in Effective Viscosity of Fluid in a Porous Medium
Investigations in Effective Viscosity of Fluid in a Porous MediumInvestigations in Effective Viscosity of Fluid in a Porous Medium
Investigations in Effective Viscosity of Fluid in a Porous Medium
 
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
Numerical Investigation of a Single Phase Air Flow inside Porous Media of a C...
 

Similar to Softgel drying model drying

T4805124135
T4805124135T4805124135
T4805124135
IJERA Editor
 
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
IJERA Editor
 
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
Michal Jablonsky
 
20120130406015
2012013040601520120130406015
20120130406015
IAEME Publication
 
Mirarco NHEET project Numerical Simulation
Mirarco NHEET project Numerical SimulationMirarco NHEET project Numerical Simulation
Mirarco NHEET project Numerical Simulation
David Cerantola
 
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Željko Penga
 
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Željko Penga
 
International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)
IJERD Editor
 
Enhancement of heat transfer rate using MgO nanofluid in heat exchanger
Enhancement of heat transfer rate using MgO nanofluid in heat exchangerEnhancement of heat transfer rate using MgO nanofluid in heat exchanger
Enhancement of heat transfer rate using MgO nanofluid in heat exchanger
IRJET Journal
 
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
IAEME Publication
 
Study of Preconditioning Procedures for Absorption and Permeability of Concrete
Study of Preconditioning Procedures for Absorption and Permeability of ConcreteStudy of Preconditioning Procedures for Absorption and Permeability of Concrete
Study of Preconditioning Procedures for Absorption and Permeability of Concrete
Dong Wang
 
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
iosrjce
 
Heat transfer to down flowing viscous films with Evaporation from the interface
Heat transfer to down flowing viscous films with Evaporation from the interfaceHeat transfer to down flowing viscous films with Evaporation from the interface
Heat transfer to down flowing viscous films with Evaporation from the interface
inventionjournals
 
1 s2.0-s0140700714001698-main pcm refrigeration
1 s2.0-s0140700714001698-main pcm refrigeration1 s2.0-s0140700714001698-main pcm refrigeration
1 s2.0-s0140700714001698-main pcm refrigeration
Himanshu Goyal
 
IRJET- Experimental Investigation on Water Desalination System based on Humid...
IRJET- Experimental Investigation on Water Desalination System based on Humid...IRJET- Experimental Investigation on Water Desalination System based on Humid...
IRJET- Experimental Investigation on Water Desalination System based on Humid...
IRJET Journal
 
Temperature Sensitive Material for the Desiccant Dehumidification System
Temperature Sensitive Material for the Desiccant Dehumidification SystemTemperature Sensitive Material for the Desiccant Dehumidification System
Temperature Sensitive Material for the Desiccant Dehumidification System
Kenneth Huang
 
Kelechukwu et al
Kelechukwu et alKelechukwu et al
Kelechukwu et al
Modesty Jnr.
 
Numerical and Experimental investigation of packed bed thermal energy storage...
Numerical and Experimental investigation of packed bed thermal energy storage...Numerical and Experimental investigation of packed bed thermal energy storage...
Numerical and Experimental investigation of packed bed thermal energy storage...
IRJET Journal
 
Thermodynamic properties and modeling of sorption isotherms for longer storag...
Thermodynamic properties and modeling of sorption isotherms for longer storag...Thermodynamic properties and modeling of sorption isotherms for longer storag...
Thermodynamic properties and modeling of sorption isotherms for longer storag...
IJMER
 
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
drboon
 

Similar to Softgel drying model drying (20)

T4805124135
T4805124135T4805124135
T4805124135
 
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
Theoretical and Statistical Models for Predicting Flux in Direct Contact Memb...
 
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
Accelerated ageing of newsprint paper: Changes in swelling ability, WRV and e...
 
20120130406015
2012013040601520120130406015
20120130406015
 
Mirarco NHEET project Numerical Simulation
Mirarco NHEET project Numerical SimulationMirarco NHEET project Numerical Simulation
Mirarco NHEET project Numerical Simulation
 
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
 
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
Penga Ž, Tolj I, Barbir F, Computational fluid dynamics study of PEM fuel cel...
 
International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)
 
Enhancement of heat transfer rate using MgO nanofluid in heat exchanger
Enhancement of heat transfer rate using MgO nanofluid in heat exchangerEnhancement of heat transfer rate using MgO nanofluid in heat exchanger
Enhancement of heat transfer rate using MgO nanofluid in heat exchanger
 
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
THERMAL CONDUCTIVITY OF NANOFLUIDS PREPARED FROM BIOBASED NANOMATERIALS DISPE...
 
Study of Preconditioning Procedures for Absorption and Permeability of Concrete
Study of Preconditioning Procedures for Absorption and Permeability of ConcreteStudy of Preconditioning Procedures for Absorption and Permeability of Concrete
Study of Preconditioning Procedures for Absorption and Permeability of Concrete
 
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
An Experimental Study on Drying Kinetics of Guava Fruit (Psidium Guajava L) B...
 
Heat transfer to down flowing viscous films with Evaporation from the interface
Heat transfer to down flowing viscous films with Evaporation from the interfaceHeat transfer to down flowing viscous films with Evaporation from the interface
Heat transfer to down flowing viscous films with Evaporation from the interface
 
1 s2.0-s0140700714001698-main pcm refrigeration
1 s2.0-s0140700714001698-main pcm refrigeration1 s2.0-s0140700714001698-main pcm refrigeration
1 s2.0-s0140700714001698-main pcm refrigeration
 
IRJET- Experimental Investigation on Water Desalination System based on Humid...
IRJET- Experimental Investigation on Water Desalination System based on Humid...IRJET- Experimental Investigation on Water Desalination System based on Humid...
IRJET- Experimental Investigation on Water Desalination System based on Humid...
 
Temperature Sensitive Material for the Desiccant Dehumidification System
Temperature Sensitive Material for the Desiccant Dehumidification SystemTemperature Sensitive Material for the Desiccant Dehumidification System
Temperature Sensitive Material for the Desiccant Dehumidification System
 
Kelechukwu et al
Kelechukwu et alKelechukwu et al
Kelechukwu et al
 
Numerical and Experimental investigation of packed bed thermal energy storage...
Numerical and Experimental investigation of packed bed thermal energy storage...Numerical and Experimental investigation of packed bed thermal energy storage...
Numerical and Experimental investigation of packed bed thermal energy storage...
 
Thermodynamic properties and modeling of sorption isotherms for longer storag...
Thermodynamic properties and modeling of sorption isotherms for longer storag...Thermodynamic properties and modeling of sorption isotherms for longer storag...
Thermodynamic properties and modeling of sorption isotherms for longer storag...
 
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
Effective Moisture Diffusivity and Activation Energy of Tomato in Thin Layer ...
 

Recently uploaded

The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Carl Bergstrom
 
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
University of Maribor
 
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdfTopic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
TinyAnderson
 
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths ForwardImmersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
Leonel Morgado
 
molar-distalization in orthodontics-seminar.pptx
molar-distalization in orthodontics-seminar.pptxmolar-distalization in orthodontics-seminar.pptx
molar-distalization in orthodontics-seminar.pptx
Anagha Prasad
 
Eukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptxEukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptx
RitabrataSarkar3
 
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
vluwdy49
 
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureDirect Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart Agriculture
International Food Policy Research Institute- South Asia Office
 
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
by6843629
 
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdfwaterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
LengamoLAppostilic
 
Bob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdfBob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdf
Texas Alliance of Groundwater Districts
 
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Sérgio Sacani
 
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
Sharon Liu
 
Micronuclei test.M.sc.zoology.fisheries.
Micronuclei test.M.sc.zoology.fisheries.Micronuclei test.M.sc.zoology.fisheries.
Micronuclei test.M.sc.zoology.fisheries.
Aditi Bajpai
 
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterSharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Texas Alliance of Groundwater Districts
 
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốtmô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
HongcNguyn6
 
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titrationCompexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Vandana Devesh Sharma
 
Applied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdfApplied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdf
University of Hertfordshire
 
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of ProteinsGBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
Areesha Ahmad
 
Equivariant neural networks and representation theory
Equivariant neural networks and representation theoryEquivariant neural networks and representation theory
Equivariant neural networks and representation theory
Daniel Tubbenhauer
 

Recently uploaded (20)

The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
 
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
 
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdfTopic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
Topic: SICKLE CELL DISEASE IN CHILDREN-3.pdf
 
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths ForwardImmersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
 
molar-distalization in orthodontics-seminar.pptx
molar-distalization in orthodontics-seminar.pptxmolar-distalization in orthodontics-seminar.pptx
molar-distalization in orthodontics-seminar.pptx
 
Eukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptxEukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptx
 
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
 
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureDirect Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart Agriculture
 
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
 
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdfwaterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
 
Bob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdfBob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdf
 
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
 
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
 
Micronuclei test.M.sc.zoology.fisheries.
Micronuclei test.M.sc.zoology.fisheries.Micronuclei test.M.sc.zoology.fisheries.
Micronuclei test.M.sc.zoology.fisheries.
 
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterSharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
 
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốtmô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
 
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titrationCompexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
 
Applied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdfApplied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdf
 
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of ProteinsGBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
 
Equivariant neural networks and representation theory
Equivariant neural networks and representation theoryEquivariant neural networks and representation theory
Equivariant neural networks and representation theory
 

Softgel drying model drying

  • 1. Mathematical Modeling of Mass and Heat Transfer to Determine Softgel Drying Rates C. Spiegel, D. Fulper Catalent Pharma Solutions Purpose The purpose of this study was to create a transient mass and heat transfer model to predict softgel drying rates in order to improve and optimize existing drying processes. The mass and heat transfer model determines the temperatures and the water concentrations in and on the surface of the gelatin film in order to understand the potential impact of changing humidity and air velocities on final capsule water activity, brittleness, and fill moisture. Methods A Matlab-based program was developed to analyze the mass and temperature distribution in a gelatin film with temperature, humidity, and air velocity with varying ribbon thickness. The total ribbon/softgel volume is divided into nodes in order to accurately calculate the drying rates. The mass and energy balances for each node are integrated simultaneously using MATLAB’s ode45 function. Arrays were created for the node water concentration, temperatures, heat flows, and thermal conductivities of each node. Fick's law is used to model the diffusion in each node. Depending upon the air velocity, either Ficks's law or convective mass transfer equations are used to model the mass transfer of water from the gelatin surface into the surrounding air. Results The results of the model showed that optimal drying of gelatin temperature is a balance between low relative humidities and low air velocities. Increased humidity (> 50%) does not allow the softgel to dry properly because the softgel shell obtains an equilibrium between the shell and the surrounding environment. Increased temperatures and velocities aid in the drying process to a certain extent, however, high velocities and temperatures are not effective due to "case hardening". The drying process can be optimized for each gelatin and fill formulation. Conclusion Simulation of gelatin drying processes can provide insight into the transport phenomena that is occurring in order to avoid costly and time-consuming experimentation. It can be used to determine optimal states of humidity, air velocity, and temperature for drying gelatin. These drying conditions determine the final percent moisture in the fill material and shell material, which in turn determines final capsule hardness, brittleness and quality.