Presentation from 10/15/13 on Nano-Materials, highlighting those used in surgical meshes. Retectix founder Matt MacEwan explains how they make nano-materials and why they solve such a major problem for so many. Join OpenlyDisruptive.org for live access to more disruptive innovation events.

1. Matthew MacEwan, MD, PhD*
Founder / President
Property of Retectix, LLC. Confidential. © 2013.

2. A COMMON PROBLEM
1 of 4

3. THE CLINICAL PAIN
>40%
FAIL

4. OUTDATED TECHNOLOGY
Woven Surgical Mesh

5. OUTDATED TECHNOLOGY
Macroscopic
Nanoscopic
≠
Woven Mesh
Human Tissue

6. A BETTER SOLUTION?
Nanoscopic
Nanoscopic
? ≠
Synthetic, Non-Woven Material?
Human Tissue

7. APPLIED NANOTECHNOLOGY
Manufacturing Process:
Nanofiber Deposition
A.) Instrumentation:
Nanofiber Monolayers
B.) Collector:
C.) Resulting Fibers
Random
+
Planar Collector
Radial
Circular Collector +
Central Point Electrode
L

8. BIO-INSPIRED DESIGN
Nanoscopic
Nanoscopic
=
RETECTIX Nanofibers
Human Tissue

9. NOVEL BIOLOGICAL PROPERTIES
Random
Aligned

10. CELLULAR MODULATION

11. THE NEXT STEP?

12. BENCHTOP TO BUSINESS
>$2 Billion Market / ASP $500
(1) Millennium Research Report,
(2) IMS 2010/2011

13. SCALING UP PRODUCTION
Nanofiber Deposition
A.) Instrumentation:
Nanofiber Monolayers
B.) Collector:
Layer Assembly
Surgical Mesh
• Proprietary methods
• Proprietary features
• Proprietary devices
• Proprietary uses
and applications
C.) Resulting Fibers
Random
+
Planar Collector
Radial
Circular Collector +
Central Point Electrode
• Proprietary method
• Proprietary equipment
• Proprietary process
• Proprietary patterns
• Proprietary designs
• Proprietary materials

14. INNOVATIVE SOLUTION
A new class of surgical mesh…

15. RAPID WOUND HEALING
Manufacturing Process:
Nanofiber Deposition
Novel Method
A.) Instrumentation:
Dura
Repaired
with
Unoperative Dura
Layer Assembly
Surgical Mesh
Cell Ingrowth
Regeneration
Radial
Nanofiber
Mesh
Nanomaterial
B.) Collector:
C.) Resulting Fibers
Nanofiber Monolayers
Dura
Re
Collag
Random
+
Planar Collector
Radial
Circular Collector +
Central Point Electrode
Animal Tissue
Unoperative Dura
Treated Collagen
(Cortical
view)
(Cortical
view)
Dura
Repaired
with
No Ingrowth
Radial
Nanofiber
Mesh
(Cortical
view)
(Cortical
view)
Dura
Repaired
with
Poor Healing
Collagen
Matrix
(Cortical
view)
(Cor

16. UNIQUE HANDLING & STRENGTH
Suture Pullout Strength (N)
18
16
14
12
10
8
6
4
2
0
DuraGen™
DuraMatrix™ DuraPatch™
DuraStar™
Cerafix™
Resistant to tears /suture pullout

17. POISED FOR GROWTH
Finished Device Manufacturer
Research & Development
Regulatory / Legal
OEM Manufacturing

18. BREAKING BOUNDARIES
Est. clinical release: Q2 2014

19. ERA OF MICROBIOLOGY…

20. … TO ERA OF NANOTECHNOLOGY

21. RETECTIX, LLC
4633 World Parkway Circle
St. Louis, MO 63134
info@retectix.com
www.retectix.com
Property of Retectix, LLC. Confidential. © 2013.