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Matt MacEwan -- Disruptive Diner: Nano Possibilities

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Presentation from 10/15/13 on Nano-Materials, highlighting those used in surgical meshes. Retectix founder Matt MacEwan explains how they make nano-materials and why they solve such a major problem for so many. Join OpenlyDisruptive.org for live access to more disruptive innovation events.

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Matt MacEwan -- Disruptive Diner: Nano Possibilities

  1. 1. Matthew MacEwan, MD, PhD* Founder / President Property of Retectix, LLC. Confidential. © 2013.
  2. 2. A COMMON PROBLEM 1 of 4
  3. 3. THE CLINICAL PAIN >40% FAIL
  4. 4. OUTDATED TECHNOLOGY Woven Surgical Mesh
  5. 5. OUTDATED TECHNOLOGY Macroscopic Nanoscopic ≠   Woven Mesh Human Tissue
  6. 6. A BETTER SOLUTION? Nanoscopic Nanoscopic ? ≠   Synthetic, Non-Woven Material? Human Tissue
  7. 7. APPLIED NANOTECHNOLOGY Manufacturing Process: Nanofiber Deposition A.) Instrumentation: Nanofiber Monolayers B.) Collector: C.) Resulting Fibers Random + Planar Collector Radial Circular Collector + Central Point Electrode L
  8. 8. BIO-INSPIRED DESIGN Nanoscopic Nanoscopic =   RETECTIX Nanofibers Human Tissue
  9. 9. NOVEL BIOLOGICAL PROPERTIES Random Aligned
  10. 10. CELLULAR MODULATION
  11. 11. THE NEXT STEP?
  12. 12. BENCHTOP TO BUSINESS >$2 Billion Market / ASP $500 (1)  Millennium Research Report, (2)  IMS 2010/2011
  13. 13. SCALING UP PRODUCTION Nanofiber Deposition A.) Instrumentation: Nanofiber Monolayers B.) Collector: Layer Assembly Surgical Mesh • Proprietary methods • Proprietary features • Proprietary devices • Proprietary uses and applications C.) Resulting Fibers Random + Planar Collector Radial Circular Collector + Central Point Electrode • Proprietary method • Proprietary equipment • Proprietary process • Proprietary patterns • Proprietary designs • Proprietary materials
  14. 14. INNOVATIVE SOLUTION A new class of surgical mesh…
  15. 15. RAPID WOUND HEALING Manufacturing Process: Nanofiber Deposition Novel Method A.) Instrumentation: Dura  Repaired  with   Unoperative Dura Layer Assembly Surgical Mesh Cell Ingrowth Regeneration Radial  Nanofiber  Mesh Nanomaterial B.) Collector: C.) Resulting Fibers Nanofiber Monolayers Dura  Re Collag Random + Planar Collector Radial Circular Collector + Central Point Electrode Animal Tissue Unoperative Dura Treated Collagen (Cortical  view) (Cortical  view) Dura  Repaired  with   No Ingrowth Radial  Nanofiber  Mesh (Cortical  view) (Cortical  view) Dura  Repaired  with   Poor Healing Collagen  Matrix (Cortical  view) (Cor
  16. 16. UNIQUE HANDLING & STRENGTH Suture Pullout Strength (N) 18 16 14 12 10 8 6 4 2 0 DuraGen™ DuraMatrix™ DuraPatch™ DuraStar™ Cerafix™ Resistant to tears /suture pullout
  17. 17. POISED FOR GROWTH Finished Device Manufacturer Research & Development Regulatory / Legal OEM Manufacturing
  18. 18. BREAKING BOUNDARIES Est. clinical release: Q2 2014
  19. 19. ERA OF MICROBIOLOGY…
  20. 20. … TO ERA OF NANOTECHNOLOGY
  21. 21. RETECTIX, LLC 4633 World Parkway Circle St. Louis, MO 63134 info@retectix.com www.retectix.com Property of Retectix, LLC. Confidential. © 2013.

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