Etiology, Sign and symptoms and pathogenesis of osteoporosis

1. Pathophysiology
Osteoporosis
Nem Kumar Jain, Rph
MS (Pharm.) Pharmacology & Toxicology
Assistant Professor, School of Pharmacy
ITM University Gwalior

2. Osteoporosis
• Osteoporosis is a condition
that is developed when the
density of the bone decreases,
• leading to a higher risk of a
fracture even by a small fall or
minor knock.
• Bone mass density (BMD)
T score = -2.5 or Less

3. Osteoporosis
Sign and Symptoms
Osteoporosis
Loss of bone density
(Porous & brittle bone)
Bone Fractures
easier than usual
with little or no trauma
simple bump or fall
•Hip
•Vertebrae
•Wrists
•elbow
Pain
Back pain: secondary to compressed
Or collapsed vertebrae
Bone pain or tenderness
Loss of Height
over the time
•stooped posture
(kyphosis)
•protrusion of belly

4. Osteoporosis
Etiology and Risk Factors

5. Pathogenesis: Inbalance in Bone REMODELLING
Osteoporosis

6. Osteoporosis