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 “Cytoskeleton is the structure that maintains the shape and
internal organization of the cell, and provides it mechanical
support. “
 The cytoskeleton is a complex network of protein fibers found in
the cytoplasm of cells. It provides shape, support, and movement
to cells.
A cytoskeleton structure comprises the following types of fibres :
 Microfilaments
 Microtubules
 Intermediate Filaments
 Microfilaments, also known as actin filaments, are one of the three main types
of fibers that make up the cytoskeleton of cells.
 They are the thinnest fibers, with a diameter of about 7 nm.
 Microfilaments are composed of the protein actin, which can polymerize to form
long chains.
 Microfilaments are involved in a variety of cellular processes, including cell
movement, cell division, and maintaining cell shape and structure.
 Microfilaments also play a role in cell signaling, as they can interact
with proteins such as myosin and other actin-binding proteins to
regulate cell behavior.
 Abnormalities in microfilaments can lead to a variety of diseases
and disorders, including cancer, autoimmune diseases such as
lupus, and genetic disorders such as Wiskott-Aldrich syndrome.
 Microtubules is most crucial cytoplasm element responsible for
maintaining the shape of the cell ,involved in cell division, responsible for
locomotion in lower organisms ,cellular movements as well as
responsible for attachment to the cell of substratum.
 They are long, hollow tubes made up of the protein tubulin, and they
have a diameter of about 25 nanometers.
 Microtubules also play a role in cilia and flagella, which are structures
that extend from the surface of cells and are involved in movement and
sensing.
 Abnormalities in microtubules can lead to a variety of diseases and
disorders, including cancer, neurodegenerative diseases such as
Alzheimer's and Parkinson's, and genetic disorders such as tuberous
sclerosis complex.
 They are thicker than microfilaments but thinner than microtubules, with
a diameter of about 10 nanometers.
 Intermediate filaments are composed of a family of proteins called
keratins, vimentin, desmin, and others, depending on the cell type.
 Intermediate filaments are involved in providing mechanical strength and
structural support to cells.
 They are particularly important in tissues that undergo mechanical stress,
such as skin, hair, and nails.
 Intermediate filaments can also help
anchor organelles such as the nucleus
and mitochondria in place within the cell.
 Responsible for muscle contraction ,
transportation
 Abnormalities in intermediate filaments
can lead to a variety of diseases and
disorders, including skin disorders such
as epidermolysis bullosa simplex and
genetic disorders such as Charcot-Marie-
Tooth disease.
 It provides shape and support to the cell.
 It helps in the formation of vacuoles.
 It holds different cell organelles in place.
 It assists in cell signalling.
 It supports intracellular movements like the migration of cell
organelles, transportation of vesicles in and out of the cell, etc.

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cell and molecular biology PPT.pptx

  • 1.
  • 2.  “Cytoskeleton is the structure that maintains the shape and internal organization of the cell, and provides it mechanical support. “  The cytoskeleton is a complex network of protein fibers found in the cytoplasm of cells. It provides shape, support, and movement to cells.
  • 3. A cytoskeleton structure comprises the following types of fibres :  Microfilaments  Microtubules  Intermediate Filaments
  • 4.  Microfilaments, also known as actin filaments, are one of the three main types of fibers that make up the cytoskeleton of cells.  They are the thinnest fibers, with a diameter of about 7 nm.  Microfilaments are composed of the protein actin, which can polymerize to form long chains.  Microfilaments are involved in a variety of cellular processes, including cell movement, cell division, and maintaining cell shape and structure.
  • 5.  Microfilaments also play a role in cell signaling, as they can interact with proteins such as myosin and other actin-binding proteins to regulate cell behavior.  Abnormalities in microfilaments can lead to a variety of diseases and disorders, including cancer, autoimmune diseases such as lupus, and genetic disorders such as Wiskott-Aldrich syndrome.
  • 6.  Microtubules is most crucial cytoplasm element responsible for maintaining the shape of the cell ,involved in cell division, responsible for locomotion in lower organisms ,cellular movements as well as responsible for attachment to the cell of substratum.  They are long, hollow tubes made up of the protein tubulin, and they have a diameter of about 25 nanometers.
  • 7.  Microtubules also play a role in cilia and flagella, which are structures that extend from the surface of cells and are involved in movement and sensing.  Abnormalities in microtubules can lead to a variety of diseases and disorders, including cancer, neurodegenerative diseases such as Alzheimer's and Parkinson's, and genetic disorders such as tuberous sclerosis complex.
  • 8.  They are thicker than microfilaments but thinner than microtubules, with a diameter of about 10 nanometers.  Intermediate filaments are composed of a family of proteins called keratins, vimentin, desmin, and others, depending on the cell type.  Intermediate filaments are involved in providing mechanical strength and structural support to cells.  They are particularly important in tissues that undergo mechanical stress, such as skin, hair, and nails.
  • 9.  Intermediate filaments can also help anchor organelles such as the nucleus and mitochondria in place within the cell.  Responsible for muscle contraction , transportation  Abnormalities in intermediate filaments can lead to a variety of diseases and disorders, including skin disorders such as epidermolysis bullosa simplex and genetic disorders such as Charcot-Marie- Tooth disease.
  • 10.  It provides shape and support to the cell.  It helps in the formation of vacuoles.  It holds different cell organelles in place.  It assists in cell signalling.  It supports intracellular movements like the migration of cell organelles, transportation of vesicles in and out of the cell, etc.