7. Three Layers
Epithelium & its Basement. 1
(Stroma & its ant condensation ( Bowman Zone. 2
( Endothelium & its Basement (Descemet Membrane.3
Structure
10. Superficial
Punctate epithelial erosions.1
Tiny ,slightly depressed, epithelial defects
which stain with flourescein but not with
rose Bengal
PEE are non specific and may develop in a
wide variety of keratopathies
Signs of Corneal Disease
21. Def: Corneal ulcers are defect in the corneal epithelium
.with or without stromal infiltration
:Types
A) Infectious ulcerative keratitis
B)Non infectious ulcerative keratitis
Corneal ulcers
23. :Causes
:Local causes
Punctate marginal keratitis: Staphylococci, Streptococci, hypersensitivity to
medications
Peripheral keratitis associated with blepharitis:
:Systemic causes
Generally manifestation of systemic, immune-mediated disease
Most common: Rheumatoid arthritis, Wegener’s granulomatosis and
polyarteritis nodosa
Non Infectious Ulcerative Keratitis
24. INFECTIOUS Non INFECTIOUS
Pain No pain
Discharge No discharge
AC reaction: present A C reaction: absent
Central Peripheral
: ++++Trauma : -------Trauma
28. ✓A corneal ulcer is anocular emergency that
raises high stakes of questions about
diagnosis and management.
✓When a large corneal ulcer is staring you in
the face time isn't in your side.
✓Despite varying etiologies and presentations,
as well as different treatment approaches ,
corneal ulcers have one thing in common : the
potential to cause devastating loss of vision.
Important Facts
29. Control of infection- 1
Control of inflammation- 2
–- 3
– lid
– bandage
- 4
Promotion of re-epithelialization
lubrication
closure
soft contact lens
Prevention of perforation
– tissue adhesive glue
– conjunctival flap
– systemic immunosuppressive agents
Corneal grafting
PRINCIPLES OF MANAGEMENT
OF CORNEAL DISEASE
39. Greyish-white ulcer with indistinct margins
Surrounded by feathery infilterates
Ring infilterate
Endothelial plaque
Hypopyon
History of vegetable matter
inj ury
40. ✓Dull grey infiltrate.
✓Satellite lesions.
✓Awareness of those ulcers resembling bacterial
keratitis
✓Awareness of those caused by yeast better
defined borders
✓Real flags
Differentiators
54. Opaque cells arranged in a course punctate
or stellate pattern
Central desquamation leads to a linear
–Fluorescein
– Rose Bengal stain
–Diminished corneal
branching ulcer.
stain
sensitivity
Anterior stromal infilterates
Geographical or amoeboid ulcer
DENDRITIC ULCER
55.
56.
57. Herpes zoster keratitis
Healing corneal abrasion
Pseudodendrites due to soft contact lens
Acanthamoeba keratitis
Drug toxicity
Differential diagnosis
58. ✓Dentritic ulcer.
✓Loss of corneal sensation.
✓Photophobia.
Types of HSV keratitis:
✓Primary
✓Recurrent
✓Dentritic , Geographic , Metaherptica
✓Diabetic foot in the eye Neurotrophic
Differentiators
63. Conjunctival: Pinkish-white nodule surrounded by
hyperaemia
Corneal: May resolve spontaneously or extend
radially to the cornea. May cause severe ulceration or
.perforation
SIGNS
64.
65. Short course of topical steroids
Topical antibiotics
TREATMENT
66. (:keratoconjunctivitis sicca (KCS
Or
keratitis sicca: is a multifactorial disease of the tears and
the ocular surface disturbance with corneal
manifestations
:Causes
Dry eye- 1
Vitamin A deficiency- 2
Keratoconjunctivitis
Sic ca
67.
68. Exposure keratopathy (EK) is the cornea damage that
occurs from prolonged exposure of the ocular surface to
. the outside environment
EK can lead to ulceration, microbial keratitis, and
permanent vision loss from scarring
:Causes
Lagophthalmos -1
Proptosis-2
Lid malposition- 3
Exposure Keratopathy
69.
70. is a degenerative disease of the cornea caused by
damage of the trigeminal nerve which results in
impairment of corneal sensitivity, spontaneous corneal
epithelium breakdown, poor corneal healing and
development of corneal ulceration, melting and
perforation
:Diagnosis
by placing a cotton wad or cotton thread in contact with
:the corneal surfaceCorneal sensitivity test
Neurotrophic keratitis