ROSETTA is a molecular modeling software package that uses ab initio structure prediction algorithms to understand protein structures, design proteins, model protein docking, and model protein-DNA and protein-protein interactions. ROSETTAFold is a three-track neural network within ROSETTA that simultaneously considers patterns in protein sequences, how amino acids interact, and possible protein structures to predict folding. To run ROSETTA, users input protein sequences that are then analyzed using ROSETTA's algorithms to predict three-dimensional protein structures and interactions.

1. ROSETTA
STRUCTURAL BIOINFORMATICS
PRESENTED BY : ZIRWA SARWAR
PRESENTED TO : DR AFSHA KALEEM

2. What is ROSETTA tool?
• ROSETTA is a molecular
modeling software package
for understanding protein
structures, protein design,
protein docking, protein-
DNA and protein-protein
interactions
• ROSETTA is mainly an ab
initio (from the begining)
structure prediction
algorithm

3. How does ROSETTA fold work?
ROSETTAFold is a “three-track” neural network,
meaning it simultaneously considers patterns in protein
sequences, how a protein's amino acids interact with
one another, and a protein's possible three-dimensional
structure.

4. How to run ROSETTA tool?