2. Homology Modeling:
Homology Modeling refers to constructing an atomic resolution model
of the target protein from its amino acid sequence and an experimental
three dimensional structure of a related homologous protein, the
template.
4. I-TASSER
Is a server that provides an Internet-based service for
protein structure prediction. It was found to be one of
the best methods in the servers section of CASP
experiments.
16. Phyre2
This modeling uses various detection tools to generate
3D structures. It has special features like ligand binding
prediction and variant analysis among the protein
amino acid sequence.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26. References:
• Muhammed, M. T., & Aki‐Yalcin, E. (2019). Homology modeling in drug discovery:
Overview, current applications, and future perspectives. Chemical biology & drug
design, 93(1), 12-20.
• Kelley, L. A., Mezulis, S., Yates, C. M., Wass, M. N., & Sternberg, M. J. (2015). The
Phyre2 web portal for protein modeling, prediction and analysis. Nature
protocols, 10(6), 845-858.
