3. IntAct
• IntAct is a central, public repository where molecular interactions data can be stored and
accessed.
• It is hosted by the European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, where it
is maintained by a group of curators and developers.
• IntAct is populated with interaction data from literature curation or direct user submissions.
• Most of the data refer to protein-protein interactions, but interactions involving other types
of molecules, such as small chemical compounds or nucleic acids, can also be found in
IntAct.
• At EMBL-EBI IntAct is the main database for molecular interactions.
4. IntAct
• IntAct is a member of the International Molecular Exchange (IMEx) Consortium
a group of major public interaction data providers whose goal is to share curation
effort and exchange completed records on molecular interaction data.
• When you query data in IntAct you also access over 11 million interactions in
around 30 data resources via our PSICQUIC (Proteomics Standard Initiative
Common QUery InterfaCe) service or a consistently annotated, non-redundant,
experimentally determined subset from the IMEx Consortium.
5. Current Status
• Binary Interactions 1,194,594
• Interactions 750,480
• Interactors 118,924
• Proteins 107,626
• Mutation Features 77,348
• Experiments 73,943
• Publications 22,954
• Nucleic Acids 4,639
6. IntAct
• Search the URL link https://www.ebi.ac.uk/legacy-intact/.
• Homepage will be opened.
7. Search Your Protein
• Enter your protein ID from UniProt e.g. COL2A1 (P02458) and search.
Details on same page
View and details on separate
page
Uniprot KB
view
14. Search Goggle
Homepage
https://www.ebi.ac.u
k/legacy-intact/.
Protein Your
Search
Protein from UniProt
e.g. COL2A1
(P02458)
Select
Customized
View
Select Standard
and Update
Select
Interactors
Select the
desired
interactor’s box
Select Search
Interactors
Result more binary
interactions
Again Click
Interactors
Select Protein
Show all the proteins
involved in
interactions
Select
Compounds
Show a list of
compound’s details
but here is zero
Select Nucleic
Acids
Show list of nucleic
acids but here is zero
Select Genes
Show a list of gene
interactors but here
is zero
Summary
