anti haemophilic factor

1. Kogenate FS
Antihemophilic
Factor
By:- MOHAMMAD SHAHAN
BSC BT II YEAR

2. PATENT INFO:-

3. Kogenate FS, Antihemophilic
Factor (Recombinant)
 Is used to treat and control bleeding
in adults and children with
hemophilia A
 May be prescribed for people with
hemophilia A when they have
surgery.
 Can reduce the number of bleeding
episodes in adults and children with
hemophilia A when used regularly
(prophylaxis) and also can reduce
the risk of joint damage in children
with hemophilia A and no pre-
existing joint damage when used
regularly.

4.  Kogenate FS Antihemophilic Factor
(Recombinant) is a coagulation factor
VIII produced by recombinant DNA
technology.
 It is produced by Baby Hamster Kidney
(BHK) cells into which the human
factor VIII gene has been introduced.
 Kogenate FS is a purified glycoprotein
consisting of multiple peptides subunit.
It has the same biological activity as
factor VIII derived from human plasma.

5. MECHANISM OF ACTION
 Antihemophilic factor (AHF) is a
protein found in normal plasma which
is necessary for clot formation.
 The administration of AHF provides an
increase in plasma levels of AHF and
can temporarily correct the
coagulation defect of patients with
hemophilia A (classical hemophilia).
 Antihemophilic Factor binds factor IXa
along with calcium and phospholipid,
This complex converts factor X to
factor Xa to facilitate clotting
cascade.

6. Common side effects of
Kogenate FS include:
 flushing of the face (warmth, redness,
itching, or tingling under your skin)
 headache.
 nausea.
 vomiting.
 fast heartbeat.
 injection site reactions (burning,
redness, irritation, swelling, or
stinging)
 fever.

7. THANK YOU