Epoetin alfa (Epogen) is a 165-amino acid glycoprotein produced using recombinant DNA technology that stimulates red blood cell production. It binds to the erythropoietin receptor and activates pathways involved in erythrocyte differentiation and maintenance of circulating red blood cell mass. Epoetin alfa is used to treat anemia by increasing reticulocyte count within 10 days and red blood cell count, hemoglobin levels within 2 to 6 weeks. Common side effects include headache, body aches, diarrhea, and joint, bone, or muscle pain.

1. EPOGEN
EPOETIN ALFA
BY:-ZOHRA AKHTAR
BSC BT II YEAR

2. DRUG PROFILE

3. DESCRIPTION
 Epoetin Alfa is a human erythropoietin produ
ced in cell culture using recombinant DNA t
echnology.
 Erythropoietin (EPO) is a growth factor prod
uced in the kidneys that stimulates the prod
uction of red blood cells.
 Epoetin Alfa is a 165-amino acid erythropoie
sis-stimulating glycoprotein produced in cell
culture using recombinant DNA technology.
 Used for the treatment of patients with ane
mia.

4. MECHANISM OF ACTION
 Erythropoietin and epoetin alfa are involved in
the regulation of erythrocyte differentiation a
nd the maintenance of a physiological level of
circulating erythrocyte mass.
 Erythropoietin or exogenous epoetin alfa bind
s to the erythropoietin receptor (EPO-R) and a
ctivates intracellular signal transduction path
ways.
 It is reported to increase the reticulocyte cou
nt within 10 days of initiation, followed by inc
reases in the RBC count, hemoglobin, usually
within 2 to 6 weeks.

5. Common side effects of Epogen includ
e:
 headache
 body aches
 diarrhea
 cold symptoms (stuffy nose, sneezing, sore
throat, cough)
 joint pain
 bone pain
 muscle pain or spasms
 dizziness

6. THANK YOU