Pangraf is the generic name for the immunosuppressant drug tacrolimus, which is used to prevent rejection in organ transplant patients. It works by inhibiting calcineurin and reducing T-lymphocyte activity in the immune system, effectively weakening the body's defenses to allow acceptance of the transplanted organ. Pangraf capsules are produced using a mutated strain of Streptomyces tsukubaensis bacteria through submerged aerobic fermentation. Close monitoring of blood pressure is recommended for patients taking this medication.

1. PANGRAF
TACROLIMUS
By:- SHEERI IRFAN
BSC BT II

3. Pangraf Capsule is an immuno-
suppressant which is used in kidney,
liver, and heart transplant patients.
Close monitoring of blood pressure is
necessary while receiving this
medicine.
It decreases the activity of immune
system to prevent an organ from
rejection.

4. Pangraf is the generic name of the drug
labeled Tacrolimus.
It is produced by a soil bacterium,
Streptomyces tsukubaensis. The
name tacrolimus is derived from
"Tsukuba macrolide
immunosuppressant".
A process for producing tacrolimus by
culturing a mutated strain of
Streptomyces in a growth medium
using submerged aerobic fermentation.

5. Mechanism of Action
It works by weakening your body's
defense system (immune system) to
help your body accept the new organ
as if it were your own.
Resulting drug-protein complex inhibits
calcineurin that in turn reduces the
activity of T-lymphocytes in the
immune system.

6. PANGRAF is owned by Proprietor
PANACEA BIOTEC LIMITED.
Word Mark: PANGRAF
Status: Registered
Class: 5
Application No.: 1196471
Proprietor: PANACEA BIOTEC LIMITED.

7. THANK YOU