3. DESCRIPTION
Alteplase is a thrombolytic drug.
Alteplase injection is used to
dissolve blood clots that have formed
in the blood vessels.
It is a tissue plasminogen activator
used to treat acute myocardial
infarctions.
4. METHOD OF
PREPAPARATION
Alteplase is an enzyme that occurs
naturally in man and causes blood
clots to dissolve.
It is a man-made protein manufactured
by recombinant DNA technology.
It is known as tissue plasminogen
activator (TPA), and is made by ovarian
cells from the Chinese hamster.
5. MECHANISM OF ACTION
Alteplase was the first recombinant
tissue-type plasminogen activator.
Recombinant tissue plasminogen
activator binds to fibrin in thrombus.
Entrapped plasminogen is converted to
plasmin by the plasminogen activator.
Plasmin conversion initiates local
fibrinolysis.