An introductory outline

1. BY: MASH’HOOD MAHMOOD
KHAN SHAHID …………….…….
D14E121

2. • Solid unit dosage form intended for insertion into body
orifices where it melts, soften or dissolves and exerts
systemic or localized effects.

3. Followings are the methods meant for manufacturing of
suppositories;
a. HAND ROLLING
b. COMPRESSION MOLDING
c. FUSION MOLDING
d. AUTOMATIC MOLDING MECHINE

4. • It is the oldest and simplest method.
• This method is employed for small scale production.
The drug is
made into fine
powder
Incorporated
into suppository
base
By trituration or
kneading
Mass is rolled
into rod shape
by fingers
Rods are cut
into pieces
Desired shape
is given by
hand

5. • This method follows the same procedure as that of hand
molding except the base containing the drug is compressed
into suppositories using a hand operated machine.
ADVANTAGES:
• It is a simple method skipping the task of hand rolling.
• Suppository formed is more elegant than hand molded one.
• It avoids the possibility of sedimentation of the insoluble solids
in the suppository base.
DISADVANTAGES:
Entrapping of air may occur causing
a. Weight variation
b. Oxidation of drug or base used.

6. • This is the approach exercised on both small and large
scale industry due to its efficacy.
• The melted mass of the base containing the drug is
poured into suppository molds.
Melt the
base
Cool it to
consistency
of thick
cream
Add
finely
powdered
solid drug
Stir until
fully
dissolved
Proceed
in usual
way

7. • This is the modern and automated method for formulation
of suppositories.
• The molding function is completely done by machine.
• Typical rotary machine turn out 3500-6000 suppositories
per hour.

8. • Omitting hand molding, rest of the methods engage a die
for imparting specific shape to the mold.
• These could of different shapes.

10. KHSN’S PRODUCTION