SUPPOSITORIES<br />TYPES AND DEFINITIONS<br />COMPOSITION AND INGREDIENTS<br />PREPARATION AND COMPOUNDING TECHNIQUES<br />
TYPES AND DEFINITIONS<br />Solid dosage form used to administer medication by way of the rectum, vagina, or urethral tract...
Rectal Suppositories<br />Tapered at either one end or both<br />Adult suppositories weigh approximately 2 grams and are f...
Vaginal Suppositories<br />Available in a variety of shapes<br />Usually weigh 3 to 5 grams each<br />Made from water solu...
Urethral Suppositories<br />Pencil shaped with a 5 mm diameter<br />Urethral suppository for a female is 50 mm in length a...
COMPOSITION AND INGREDIENTS<br />Bases used in compounding suppositories should be stable, nonirritating, and both chemica...
PREPARATION AND COMPOUNDING TECHNIQUES<br />Hand molding suppositories requires skills achieved with experience<br />Use c...
PREPARATION AND COMPOUNDING TECHNIQUES	<br />Fusion method the base is melted using a water bath on a hotplate and poured ...
CONCLUSION<br />When preparing suppositories, it is always advisable to prepare 10 percent excess to allow for loss during...
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C:\Documents And Settings\Loretta Conners\My Documents\Rasmussen\Assignments\Unit Dose\Lconners Suppositories 012810

  1. 1. SUPPOSITORIES<br />TYPES AND DEFINITIONS<br />COMPOSITION AND INGREDIENTS<br />PREPARATION AND COMPOUNDING TECHNIQUES<br />
  2. 2. TYPES AND DEFINITIONS<br />Solid dosage form used to administer medication by way of the rectum, vagina, or urethral tract<br />Melt or undergo dissolution at body temperature, delivering needed drug either locally or systemically<br />
  3. 3. Rectal Suppositories<br />Tapered at either one end or both<br />Adult suppositories weigh approximately 2 grams and are from 1 to 1-1/2 inch long<br />Infant suppositories are half the size of adult suppositories<br />
  4. 4. Vaginal Suppositories<br />Available in a variety of shapes<br />Usually weigh 3 to 5 grams each<br />Made from water soluble bases such as polyethylene glycols or glycerinated gelatin<br />Another form is a compressed tablet, also known as an insert<br />
  5. 5. Urethral Suppositories<br />Pencil shaped with a 5 mm diameter<br />Urethral suppository for a female is 50 mm in length and weighs approximately 2 grams<br />Urethral suppository for a male is 125 mm in length and weighs about 4 grams<br />Urethral suppositories are rarely prescribed<br />
  6. 6. COMPOSITION AND INGREDIENTS<br />Bases used in compounding suppositories should be stable, nonirritating, and both chemically and physiologically inactive, and dissolve in the body cavity where inserted<br />Choose base, considering patient sensitivities to ingredients, drug-base compatibility, solubility, stability, rate of release of drug, amount of drug to be incorporated, local or systemic effect<br />
  7. 7. PREPARATION AND COMPOUNDING TECHNIQUES<br />Hand molding suppositories requires skills achieved with experience<br />Use cocoa butter as base, cocoa butter is grated, weighed, and mixed with active ingredient using a mortar and pestle<br />Mixture becomes a solid form, shape with hands into long cylinder, cut into desire length, and round the tip.<br />
  8. 8. PREPARATION AND COMPOUNDING TECHNIQUES <br />Fusion method the base is melted using a water bath on a hotplate and poured into pre-calibrated molds.<br />Active ingredient and excipients are stirred into the completely liquefied base<br />Suppositories are cooled and hardened at room temperature, the excess is trimmed using a clean single-edge razor or heated spatula<br />
  9. 9. CONCLUSION<br />When preparing suppositories, it is always advisable to prepare 10 percent excess to allow for loss during preparation and for overfilling<br />

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