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oncogenesis
RNA oncogenic viruses
VIRUS HOST ASSOCIATED TUMOUR
1. ACUTE TRANSFORMING VIRUSES
Rous sarcoma virus
Leukaemia-sarcoma virus
Chickens
Avian, feline, bovine, primate
Sarcoma
Leukaemias, sarcomas
2. SLOW TRANSFORMING VIRUSES
Mouse mammary tumour (Bittner milk
factor)
Mice, cats, bovine
Daughter mice
Leukaemias, lymphomas
Breast cancer
3. HUMAN T-CELL LYMPHOTROPIC VIRUS
(HTLV)
HTLV-1
HTLV-2
Human
Human
Adult t-cell leukaemia lymphoma(ATLL)
T-CELL variant of hairy cell leukaemia
4. HEPATITIS C VIRUS
HCV Human Hepatocellular carcinoma
DNA oncogenic viruses
VIRUS HOST ASSOCIATED TUMOUR
1. PAPOVAVIRUSES
Human papilloma virus
Papiloma viruses
Polyma virus
Merkel cell polyoma virus
SV-40 virus
Humans
Cotton-tail rabbits
Bovine
Mice
Humans
Monkeys
Hamsters
Humans
Cervical cancer and its precursor lesions
Squamous cell carcinoma at other sites
Skins cancer in epidermodysplasia verruciformis
Papilomas (warts) on skin, lrynx, genitals (genital warts)
Papilomas (warts)
Alimentary tract cancer
Various carcinomas , sarcomas
Merkel cell carcinoma
Harmless
Sarcoma
?Mesothelioma
2. HERPESVIRUSES
Epstein-Barr virus
Human herpesvirus 8
(Kaposi sarcoma herpesvirus)
Humans
Humans
Barkitt lymphoma
Nasopharyngeal carcinoma
Kaposi sarcoma
Pleural effusion lymphoma
3. ADENOVIRUSES Hamsters Sarcomas
4. POXYVIRUSES Rabbits
Humans
Myxomatosis
Papilloma
5. HEPADNAVIRUSES
Hepatitis B Virus Humans Hepatocellular carcinoma
VIRUS CAUSING HUMAN CANCERS
VIRUS FAMILY VIRUS HUMAN CANCER
Papillomaviridae Human Papilloma virus Genital tumors
Squamous cell carcinoma
Oropharyngeal carcinoma
Herpesviridae Epstein- Barr virus Nasopharyngeal carcinoma
Burkitt’s lymphoma
Hodgkin disease
B cell lymphoma
Human Herpes virus 8 Kaposi sarcoma
Hepadnaviridae Hepatitis B virus Hepatocellular carcinoma
Flaviviridae Hepatitis C virus Hepatocellular carcinoma
Retroviridae Human T cell lymphoma virus Adult T cell lymphoma
Human immunodeficiency virus AIDS related malignancies

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ONCOGENESIS.pptx

  • 2. RNA oncogenic viruses VIRUS HOST ASSOCIATED TUMOUR 1. ACUTE TRANSFORMING VIRUSES Rous sarcoma virus Leukaemia-sarcoma virus Chickens Avian, feline, bovine, primate Sarcoma Leukaemias, sarcomas 2. SLOW TRANSFORMING VIRUSES Mouse mammary tumour (Bittner milk factor) Mice, cats, bovine Daughter mice Leukaemias, lymphomas Breast cancer 3. HUMAN T-CELL LYMPHOTROPIC VIRUS (HTLV) HTLV-1 HTLV-2 Human Human Adult t-cell leukaemia lymphoma(ATLL) T-CELL variant of hairy cell leukaemia 4. HEPATITIS C VIRUS HCV Human Hepatocellular carcinoma
  • 3. DNA oncogenic viruses VIRUS HOST ASSOCIATED TUMOUR 1. PAPOVAVIRUSES Human papilloma virus Papiloma viruses Polyma virus Merkel cell polyoma virus SV-40 virus Humans Cotton-tail rabbits Bovine Mice Humans Monkeys Hamsters Humans Cervical cancer and its precursor lesions Squamous cell carcinoma at other sites Skins cancer in epidermodysplasia verruciformis Papilomas (warts) on skin, lrynx, genitals (genital warts) Papilomas (warts) Alimentary tract cancer Various carcinomas , sarcomas Merkel cell carcinoma Harmless Sarcoma ?Mesothelioma
  • 4. 2. HERPESVIRUSES Epstein-Barr virus Human herpesvirus 8 (Kaposi sarcoma herpesvirus) Humans Humans Barkitt lymphoma Nasopharyngeal carcinoma Kaposi sarcoma Pleural effusion lymphoma 3. ADENOVIRUSES Hamsters Sarcomas 4. POXYVIRUSES Rabbits Humans Myxomatosis Papilloma 5. HEPADNAVIRUSES Hepatitis B Virus Humans Hepatocellular carcinoma
  • 5. VIRUS CAUSING HUMAN CANCERS VIRUS FAMILY VIRUS HUMAN CANCER Papillomaviridae Human Papilloma virus Genital tumors Squamous cell carcinoma Oropharyngeal carcinoma Herpesviridae Epstein- Barr virus Nasopharyngeal carcinoma Burkitt’s lymphoma Hodgkin disease B cell lymphoma Human Herpes virus 8 Kaposi sarcoma Hepadnaviridae Hepatitis B virus Hepatocellular carcinoma Flaviviridae Hepatitis C virus Hepatocellular carcinoma Retroviridae Human T cell lymphoma virus Adult T cell lymphoma Human immunodeficiency virus AIDS related malignancies