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INMUNOLOGÍA
CISNEROS G PABLO
GENERALIDADES
RESPUESTA INMUNITARIA
• MEDIADA POR EL SISTEMA
INMUNITARIO
• INMUNIDAD INNATA
• INMUNIDAD ADAPTATIVA
• ANTICUERPO
• ANTIGENO
• PROPORCIONAN PROTECCION Y
DEFENSA EN EL HOSPEDERO CONTRA
ENFERMEDADES
BARRERA DE LA INMUNIDAD
PIEL
LIZOSINAS - DEFENSINAS
MOCO
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange,
RESPUESTAS INNATAS
SENSORES ANTIMICROBIANOS
•TLR, NLR, RIG-1 Y MDA-5
COMPONENTE CELULAR Y FAGOCITICO
•QUIMIOTAXIS
•MIGRACION
•INGESTION
•DESTRUCCION 1) ACIDO 2) PEPTIDOS 3) H2O2 4) NO2
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
LINFOCITOS ASESINOS NATURALES
•LINF NK RECP: 1) NK (LECITINAS) 2) KIR
SISTEMA DE COMPLEMENTO
•PROTEINAS DE DEFENSA
MEDIADORES DE INFLAMACION
•CITOCINAS, INTERLEUCINAS, INTERFERONES,
MEDIADORES DE INFLAMACION
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
RESPUESTA ADAPTATIVA
CELULAR LINFOCITOS T
ACTIVAN LA INMUNIDAD HUMORAL
USAN EL COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD
HUMORAL LINFOCITOS B
MEDIADOS CON SELECCIÓN CLONAL
ANTICUERPOS O INMUNOGLOBULINAS
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
CARACTERISTICAS
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford,
CT: Appleton & Lange,
RESPUESTA
CELULAR Y MCH
• MAYORMENTE
BACTERIANO
MCH
TIPO II
• MAYORMENTE
VIRAL
MCH
TIPO I
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford,
SUPERANTIGENOS
• NO REQUIEREN
PROCESAMIENTO
• ESTIMULAN MAYOR
CANTIDAD DE
LINFOCITOS
• ESTAFILOCOCICAS
• ESTREPTOCOCICAS
• TORMENTA DE
CITOSINAS
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
RESPUESTA HUMORAL Y ANTICUERPOS
• MEDIADO POR LINFOCITOS B
• 1) BCR PRESENTA AG POR EL MHC II
• 2) ACTÚAN TH HELPER Y T CD4+
• 3) ACTIVAN CITOSINAS QUIMIO-
TACTICAS
• 4) INDUCE PRODUCCIÓN DE MAS LINF
B POR INTER-LEUCINAS
• 5) TRANSFORMACIÓN EN LÍNEAS
CELULARES 1- PLASMÁTICAS O 2- B
DE MEMORIA
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed.
Stamford, CT: Appleton & Lange.
CLASES DE INMUNOGLOBULINAS
IgG 80%. Crónica. Cruza placenta
IgM 5%. Aguda. Signos de infección intrautero
IgA 15%. Mucosas. Leche, Saliva y Lagrimas
IgE Estimula complejo antígeno anticuerpo (ANAFILAXIA)
IgD ???
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
SISTEMA DE
COMPLEMENTO
VIA CLASICA
VIA ALTERNATIVA
VIA DE LA LECITINA
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz,
Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
RESPUESTA PRIMARIA Y SECUNDARIA
• FUNCIONES
• POTENCIA FAGOCITOSIS
• NEUTRALIZA VIRUS
• NEUTRALIZA TOXINAS
• LISIS POR COMPLEMENTO
• CITOTOXICIDAD CELULAR
INMUNIDAD
ACTIVA
PASIVA
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and
Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical
microbiology. 27th ed. Stamford, CT: Appleton & Lange.
CÉLULAS
T
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed.
HIPERSENSIBILIDAD
TIPOS:
I, II, III
ANTICUERPOS
IV
LINFOCITOS T
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
TIPOS DE HIPERSENSIBILIDAD
TIPO I
•IgE
•Anafilaxia
•Colabora la
Histamina y
prostaglandinas
TIPO II
•IgG
•Lisis celular
•Colabora el
complemento
TIPO III
•Complejo
inmune
•Complemento
C3
•Infecciones
prolongadas
TIPO IV
•Linfocitos T
•Proliferación
monoclonal
•Eritemas
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
DEFECTOS DE LA RESPUESTA INMUNITARIA
•Infecciones
•Tumores
•Medicamentosas
Inmuno deficiencias (primarias – secundarias)
Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick &
Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.

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inmunología.pptx

  • 2. GENERALIDADES RESPUESTA INMUNITARIA • MEDIADA POR EL SISTEMA INMUNITARIO • INMUNIDAD INNATA • INMUNIDAD ADAPTATIVA • ANTICUERPO • ANTIGENO • PROPORCIONAN PROTECCION Y DEFENSA EN EL HOSPEDERO CONTRA ENFERMEDADES BARRERA DE LA INMUNIDAD PIEL LIZOSINAS - DEFENSINAS MOCO Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange,
  • 3. RESPUESTAS INNATAS SENSORES ANTIMICROBIANOS •TLR, NLR, RIG-1 Y MDA-5 COMPONENTE CELULAR Y FAGOCITICO •QUIMIOTAXIS •MIGRACION •INGESTION •DESTRUCCION 1) ACIDO 2) PEPTIDOS 3) H2O2 4) NO2 Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 4. LINFOCITOS ASESINOS NATURALES •LINF NK RECP: 1) NK (LECITINAS) 2) KIR SISTEMA DE COMPLEMENTO •PROTEINAS DE DEFENSA MEDIADORES DE INFLAMACION •CITOCINAS, INTERLEUCINAS, INTERFERONES, MEDIADORES DE INFLAMACION Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 5. RESPUESTA ADAPTATIVA CELULAR LINFOCITOS T ACTIVAN LA INMUNIDAD HUMORAL USAN EL COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD HUMORAL LINFOCITOS B MEDIADOS CON SELECCIÓN CLONAL ANTICUERPOS O INMUNOGLOBULINAS Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 6. CARACTERISTICAS Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange,
  • 7. RESPUESTA CELULAR Y MCH • MAYORMENTE BACTERIANO MCH TIPO II • MAYORMENTE VIRAL MCH TIPO I Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford,
  • 8. SUPERANTIGENOS • NO REQUIEREN PROCESAMIENTO • ESTIMULAN MAYOR CANTIDAD DE LINFOCITOS • ESTAFILOCOCICAS • ESTREPTOCOCICAS • TORMENTA DE CITOSINAS Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 9. RESPUESTA HUMORAL Y ANTICUERPOS • MEDIADO POR LINFOCITOS B • 1) BCR PRESENTA AG POR EL MHC II • 2) ACTÚAN TH HELPER Y T CD4+ • 3) ACTIVAN CITOSINAS QUIMIO- TACTICAS • 4) INDUCE PRODUCCIÓN DE MAS LINF B POR INTER-LEUCINAS • 5) TRANSFORMACIÓN EN LÍNEAS CELULARES 1- PLASMÁTICAS O 2- B DE MEMORIA Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 10. CLASES DE INMUNOGLOBULINAS IgG 80%. Crónica. Cruza placenta IgM 5%. Aguda. Signos de infección intrautero IgA 15%. Mucosas. Leche, Saliva y Lagrimas IgE Estimula complejo antígeno anticuerpo (ANAFILAXIA) IgD ??? Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 11. SISTEMA DE COMPLEMENTO VIA CLASICA VIA ALTERNATIVA VIA DE LA LECITINA Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 12. RESPUESTA PRIMARIA Y SECUNDARIA • FUNCIONES • POTENCIA FAGOCITOSIS • NEUTRALIZA VIRUS • NEUTRALIZA TOXINAS • LISIS POR COMPLEMENTO • CITOTOXICIDAD CELULAR INMUNIDAD ACTIVA PASIVA Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 13. CÉLULAS T Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed.
  • 14. HIPERSENSIBILIDAD TIPOS: I, II, III ANTICUERPOS IV LINFOCITOS T Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 15. TIPOS DE HIPERSENSIBILIDAD TIPO I •IgE •Anafilaxia •Colabora la Histamina y prostaglandinas TIPO II •IgG •Lisis celular •Colabora el complemento TIPO III •Complejo inmune •Complemento C3 •Infecciones prolongadas TIPO IV •Linfocitos T •Proliferación monoclonal •Eritemas Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.
  • 16. DEFECTOS DE LA RESPUESTA INMUNITARIA •Infecciones •Tumores •Medicamentosas Inmuno deficiencias (primarias – secundarias) Jawetz, E., Brooks, G., Butel, J., Morse, S., Melnick, J. and Adelberg, E. (1998). Jawetz, Melnick & Adelberg's medical microbiology. 27th ed. Stamford, CT: Appleton & Lange.