Trabalho de Conclusão de Curso: Imunossenescência. Como o envelhecimento afeta as células do sistema imune?

1. Imunossenescência
Aluna: Bárbara Hamaguchi
Orientação: Prof. Dr. Michelangelo Juvenale
Trabalho de Conclusão de Curso – Biomedicina/2015

2. 2040
1,3 Bilhões
de idosos
OMS, 2015.

3. 14%da população
mundial
ONU, 2014.

4. fatores
MUDARAM
Alguns

5. Viver mais, é diferente
de viver melhor

6. Objetivo
Descrever os efeitos do envelhecimento
sobre as células sistema imunológico

7. Método
Revisão de literatura em bases de dados e livros.
Imunossenescência; involução tímica; imunidade
adaptativa; inata; inflammaging.
Descritores

8. Imunossenescência

9. Involução
Tímica
Adaptação ou deterioramento?

10. HAYNES et al., 2000.
GAPS
IMUNOLÓGICOS
Foxn1
T naïve

11. Soma descartável
Evitar autoimunidade
Mais memória
“Ajuste fino”
?
(ARONSON, 1991)
(GEORGE e RITTER, 1996)
(DOWLING e HODGKIN, 2009)
(O’LEARY e HALLGREN, 2009)

12. T CD8+ CD27- CD28- /CD45+
CMV
CD56
Anergia
Resistência à
apoptose
(LOONEY et al., 1999; MCLEOD, 2001; PAWELEC et al., 2006; WENG, AKBAR e GORONZY, 2009)

13. CD4:CD8 < 1

14. Linfócitos B
Proteína E47
Aicda
AID
Switch de
classe
(FRASCA et al., 2007; LANDIN et al., 2011)

15. (BEERMAN et al., 2010; ROSSI et al., 2005)

16. QUIMIOTAXIA
PI3K
SAPEY et al., 2014. A relação da
Neutrófilos
(Quinase fosfatidil-inositol 3)

17. Neutrófilos
Fagocitose
NET
EROs
BRUBAKER et al., 2013; BUTCHER et al., 2004; TSENG et al., 2012

18. Macrófagos/monócitos
In vivo
Ex vivo
IL-6
TNF-α
IL -1β
CD16+CD14+
(GOMEZ et al., 2009; RENSHAW et al., 2002; SEIDLER et al., 2010)

19. Células NK
Células TCD8+
(LOPES-VERGÈS et al., 2011; SUN et al., 2011)

20. “Inflammaging”
Immune Risk Profile (IRP)
TNF-α
IL-8
(WIKBY et al., 1994; 1998; 2002; 2006)

21. De que maneira os
são diferentes?
Centenários saudáveis
(DE MARTINIS et al., 2005; FRANCESCHI et al., 2000)

22. Considerações finais
Adaptação Imunossenescência

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BEERMAN, I. et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a
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BRUBAKER, A. L. et al. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound
infection with advanced age. The Journal of Immunology, v. 190, n. 4, p. 1746-1756, 2013.
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DE MARTINIS, M. et al. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS
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FRANCESCHI, C. et al. The network and the remodeling theories of aging: historical background and new perspectives.
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