The pentose phosphate pathway is also called the Hexose monophosphate pathway/ HMP shunt/ Phosphogluconate pathway. It is an alternative route for the metabolism of glucose. It is a more complex pathway than glycolysis. It is more anabolic. It takes place in the cytosol. The tissues such as the liver, adipose tissue, adrenal gland, erythrocytes, testes, and lactating mammary gland are highly active in the HMP shunt. It is concerned with the biosynthesis of NADPH and pentoses.

1. HMP Shunt/ PP Pathway
Dr. Saman Hina

2. HEXOSE MONOPHOSPHATE (HMP)
SHUNT
An Alternate Pathway for Oxidation of Glucose
Synonyms: Variously called as:
• Hexose monophosphate pathway or shunt
• Pentose phosphate pathway (PP-pathway)
• Pentose cycle
• Phosphogluconate pathway
• Warburg-Dickens-Lipman Pathway.

4. Difference between EMP and HMP

5. METABOLIC PATHWAYS
Reactions of this pathway can be considered arbitrarily in 2 stages
Stage I: (Oxidative Phase)
Oxidation of Glucose and formation of Pentose Phosphates (Oxidative Phase).
Stage II: (Non-oxidation Phase)
• Pentose phosphate reactions (Interconversion of
Pentoses)
• Conversion of pentose phosphates to hexose phosphates.

7. Stage I: Oxidation of Glucose and Formation
of Pentose phosphates (Oxidative phase):

8. Second oxidative step

9. Stage II-Non-Oxidative Phase