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Language Disorders
Medical and Psychosocial
Aspects of Disability
By: Hina Khalid
Communication
 There are 3 elements in this exchange,
and all must be present:
1. Message
2. Message must be expressed
3. Message must be understood
Speech and Language
 Speech is the motor act of
communicating by articulating verbal
expression
 Language is the knowledge of a
symbol system used for interpersonal
communication.
Four domains of language
Phonology
Grammar
Semantics
Pragmatics
Phonology
 The ability to produce and
discriminate the specific sounds of a
given language.
 Its unit, the phoneme, is characterized
by distinctive features.
 Babies start discriminating phonemes
during the first few months of life, and
they produce them soon after.
Phonology
 Phonological receptivity is pluripotential
at birth
 Starts to decay at around 10 months
 Reaches a rather general inability to
acquire native phonology by
preadolescence
Grammar
 The underlying rules that organize
any specific language.
 The combinatorial rules that most native
speakers of a language recognize as
acceptable for that language and that
allow a native speaker an infinite array
of generative possibilities.
Grammar
 Composed of both morphology and
syntax.
Semantics
 The study of meaning
 Includes the study of vocabulary
(lexicon).
Lexicon
 Lexical entries are organized in the
mental dictionary according to well-
defined rules
 Allows the young child to acquire a
peak average of 10 new words per day.
 By 24 months the average child knows
50 words.
Lexicon Growth
 The subsequent
exponential growth
makes it difficult to
determine
vocabulary size with
exactitude.
Environmental factors
predicting large vocabularies
 Reading and discussing children's stories
 The quality of dinner table conversations
 Large mother-produced number of words
 Higher socioeconomic status (SES)
 Being the firstborn ( Hoff-Ginsberg, 1998 )
 Quantity and sophistication of mother's
vocabulary ( Snow, 1998 ).
Pragmatics
 A number of sub-domains reflecting
communicative competence.
Sub domains of Pragmatics
 Rules of conversation (turn-taking, topic
maintenance, conversational repair)
 Politeness
 Narrative and extended discourse
 The implementation of communicative
intents
Pragmatic disorders
 Little variety in language use
 May say inappropriate or unrelated
things during conversations
 May tell stories in a disorganized way
 Can often make demands, ask
questions, and greet people
 Has trouble organizing language to talk
about what happened in the past.
Pragmatic disorders
 Appear to pull topics out of the air
 May not use statements that signal a
change in topic, such as "That reminds
me."
 Peers may avoid having conversations
with such a child.
 Can lower social acceptance.
Language Developmental
Trajectory
Canonical Babbling
Word comprehension
Word production
Word combinations
Telegraphic speech
Continue…..
 By age 3, most
normal children
have mastered the
basic structures of
their native
language
Language acquisition
 Occurs with uniformity and rapidity
 Supports the hypothesized existence of
innate, genetically determined Universal
Grammars
 Recently proposed a combination of
traditional learning and innate language
modules.
Disfluencies in Children
 Almost all children go through a stage
of frequent disfluency
 usually between the ages of 2 and 5.
 Speech is produced easily in spite of
the disfluencies.
Etiology of Speech & Language
Disorders
 Mental retardation
 Hearing loss
 Maturation delay
(developmental
language delay)
 Expressive
language disorder
(developmental
expressive aphasia)
 Bilingualism
 Psychosocial
deprivation
 Autism
 Elective mutism
 Receptive aphasia
 Cerebral palsy
Overview of major types of
speech disordersspeech disorders
 Definitions vary, but
generally agree that
speech disorders involve
deviations of sufficient
magnitude to interfere
with communication.
 They draw attention to
the speaking act and
away from the message
1. Fluency Disorders
 Speech is characterized by repeated
interruptions, hesitations, or repetitions
 Stuttering is by far the most well-
known fluency disorder
1. Stuttering
 Flow of speech is abnormally
interrupted by repetitions, blocking, or
prolongations of sounds, syllables,
words, or phrases
 Very familiar, but actually quite rare –
only 1-5% of the population.
 Articulation disorders actually occur
much more frequently than stuttering
Stuttering -- Causes
 Still a mystery
 Three perspectives:
1. Symptom of emotional
disturbance
2. Result of biological
makeup
3. Learned response
Stuttering
 Disorder of speech fluency that
interrupts the forward flow of speech.
 All individuals are disfluent at times
 Differentiated by the kind and amount of
the disfluencies
Characteristics-Repetition
 Sounds
 b-b-b-ball
 Syllables
 mo-mo-mommy
 Parts of words
 basket-basket-basketball
 Whole words, and phrases
Characteristics-Prolongation
 Stretching, of sounds or syllables
 r-----abbit
Characteristics
 Tense pauses, hesitations, and/or no
sound between words
 Speech that occurs in spurts
 as the child tries to initiate or maintain
voice
 Variability in stuttering behavior
 depending on the speaking situation
Related behaviors
 tense muscles in the lips, jaw, and/or
neck
 tremor of the lips, jaw, and/or tongue
 foot tapping
 eye blinks
 head turns
2. Articulation disorders
 This is the largest category of all
speech problems
 DSM-IV calls these “phonological
disorders.”
 “abnormal speech-sound production,
characterized by inaccurate or
otherwise inappropriate execution of
speaking”
2. Articulation disorders
 Great majority are functional articulation
disorders
 Might represent as much as 80% of the
speech disorders diagnosed by speech
clinicians
 Must be very careful to distinguish true
problems from delay.
 E.g., r, s, th problems may largely disappear
naturally after 5 years of age
2. Articulation disorders
1. Omissions
2. Substitutions
3. Additions
4. Distortions
3. Voice disorders
 Unusual or abnormal acoustical
qualities in the sounds made when a
person speaks
 Very little research here
 What is a “normal” sounding voice?
 Nasality, hoarseness, breathiness
Normal Speech Development
4. Delayed speech
 Failure to develop speech at the
expected age
 Somewhat subjective
 Usually associated with other
maturational delays
 May also be associated with a hearing
impairment, mental retardation,
emotional disturbance, or brain injury
 Often the result of environmental
deprivation
Epidemiology of Speech Delay
 Common childhood problem
 Affects 3 to 10 percent of children.
 3-4X more common in boys than in
girls.
Most common causes of speech
delay
Mental retardation
Hearing loss
Maturation delay
Overview of major types of
language disorderslanguage disorders
 Need to understand normal language
and prelanguage development
 See Table 10.1 on 320
 May involve comprehension
(understanding) or expression in
written or spoken language
 These are very complex to diagnose
and treat
Language and Brain
Language disordersLanguage disorders
1. Expressive language disorders
2. Receptive language disorders
3. Aphasia – loss of the ability to speak
or comprehend language because of
an injury or developmental
abnormality in the brain
EXPRESSIVE LANGUAGE
DISORDER
(developmental expressive aphasia)
 Fail to develop the use of speech at the
usual age.
EXPRESSIVE LANGUAGE DISORDER
 Normal intelligence
 Normal hearing
 Good emotional relationships
 Normal articulation skills.
 Comprehension of speech is
appropriate to the age of the child
EXPRESSIVE LANGUAGE DISORDER
 Brain dysfunction
that results in an
inability to
translate ideas
into speech.
EXPRESSIVE LANGUAGE DISORDER
 The child is at risk for language-based
learning disabilities (dyslexia).
 May use gestures to supplement their
limited verbal expression .
Maturation Delay vs. Expressive
Language Disorder?
 The late bloomer will
eventually develop
normal speech
 The child with an
expressive language
disorder will not do
so without
intervention.
Maturation Delay vs. Expressive
Language Disorder?
It is sometimes difficult, if not
impossible, to distinguish at
an early age a late bloomer
from a child with an
expressive language disorder.
BILINGUALISM
 A bilingual home
environment may
cause an apparent
temporary delay in
the onset of both
languages.
BILINGUALISM
 The bilingual child's comprehension of
the two languages is normal for a child
of the same age.
 Usually becomes proficient in both
languages before the age of five years.
Interference or transfer
 An English error due to the direct
influence of the primary language
structure.
 This is a normal phenomenon
Silent period
 Common second-language acquisition
phenomenon
 Often very quiet, speaking little
 Focus on understanding the new
language
 The younger the child, the longer the
silent period tends to last.
Code switching
 Changing languages over phrases or
sentences.
 Normal phenomenon
Benefits of Bilingualism
 Children who are fluent bilinguals
actually outperform monolingual
speakers on tests of metalinguistic skill.
Benefits of Bilingualism
 Our world is shrinking and business
becomes increasingly international
 Children who are fluent bilingual
speakers are potentially a tremendously
valuable resource for the U.S.
economy.
Language Disorders
 Egyptians reported
speech loss after
blow to head 3000
years ago
 Broca (1861) finds
damage to left inferior
frontal region (Broca’s
area) of a language
impaired patient, in
postmortem analysis
Language Disorders
 In language disorders
 90-95% of cases, damage is to the left
hemisphere
 5-10% of cases, to the right hemisphere
 Wada test is used to determine the
hemispheric dominance
 Sodium amydal is injected to the carotid artery
 First to the left and then to the right
Language Disorders
 Paraphasia:
 Substitution of a word by a sound, an incorrect
word, or an unintended word
 Neologism:
 Paraphasia with a completely novel word
 Nonfluent speech:
 Talking with considerable effort
 Agraphia:
 Impairment in writing
 Alexia:
 Disturbances in reading
Three major types of Aphasia
Rosenzweig: Table 19.1, p. 615
 Borca’s aphasia
 Nonfluent speech
 Wernicke’s aphasia
 Fluent speech but unintelligible
 Global aphasia
 Total loss of language
Others: Conduction, Subcortical, Transcortical
Motor/Sensory (see also Kandel, Table 59-1)
Brain areas involved in Language
Broca’s Aphasia
Brodmann 44, 45
 Lesions in the left inferior frontal region
(Broca’s area)
 Nonfluent, labored, and hesitant speech
 Most also lost the ability to name persons or
subjects (anomia)
 Can utter automatic speech (“hello”)
 Comprehension relatively intact
 Most also have partial paralysis of one side of
the body (hemiplegia)
 If extensive, not much recovery over time
Wernicke’s
Aphasia
Brodmann 22, 30
 Lesions in posterior of the left superior
temporal gyrus, extending to adjacent parietal
cortex
 Fluent speech
 But contains many paraphasias
 “girl”-“curl”, “bread”-“cake”
 Syntactical but empty sentences
 Cannot repeat words or sentences
 Unable to understand what they read or hear
 Usually no partial paralysis
Wernicke-Geschwind Model
1. Repeating a spoken word
 Arcuate fasciculus is the bridge from the
Wernicke’s area to the Broca’s area
Wernicke-Geschwind Model
2. Repeating a written word
 Angular gyrus is the gateway from visual cortex to
Wernicke’s area
 This is an oversimplification of the issue:
 not all patients show such predicted behavior (Howard,
1997)
Sign Languages
 Full-fledged languages, created by hearing-
impaired people (not by Linguists):
 Dialects, jokes, poems, etc.
 Do not resemble the spoken language of the same
area (ASL resembles Bantu and Navaho)
 Pinker: Nicaraguan Sign Language
 Another evidence of the origins of language (gestures)
 Most gestures in ASL are with right-hand, or
else both hands (left hemisphere dominance)
 Signers with brain damage to similar regions
show aphasia as well
Signer Aphasia
 Young man, both spoken and sign language:
 Accident and damage to brain
 Both spoken and sign languages are affected
 Deaf-mute person, sign language:
 Stroke and damage to left-side of the brain
 Impairment in sign language
 3 deaf signers:
 Different damages to the brain with different
impairments to grammar and word production
Spoken and Sign Languages
 Neural mechanisms are similar
 fMRI studies show similar activations for
both hearing and deaf
 But in signers, homologous activation
on the right hemisphere is unanswered
yet
Dyslexia
 Problem in learning to read
 Common in boys and left-handed
 High IQ, so related with language only
 Postmortem observation revealed anomalies
in the arrangement of cortical cells
 Micropolygyria: excessive cortical folding
 Ectopias: nests of extra cells in unusual location
 Might have occurred in mid-gestation, during
cell migration period
Acquired Dyslexia = Alexia
 Disorder in adulthood as a result of
disease or injury
 Deep dyslexia (pays attn. to wholes):
 “cow” -> “horse”, cannot read abstract
words
 Fails to see small differences (do not read
each letter)
 Problems with nonsense words
 Surface dyslexia (pays attn. to details):
 Nonsense words are fine
 Suggests 2 different systems:
 One focused on the meanings of whole
words
Electrical Stimulation
 Penfield and Roberts (1959): During epilepsy
surgery under local anesthesia to locate
cortical language areas, stimulation of:
 Large anterior zone:
 stops speech
 Both anterior and posterior temporoparietal cortex:
 misnaming, impaired imitation of words
 Broca’s area:
 unable comprehend auditory and visual semantic
material,
 inability to follow oral commands, point to objects, and
understand written questions
Studies by Ojemann et al.
 Stimulation of the brain of an English-Spanish
bilingual shows different areas for each
language
 Stim of inferior premotor frontal cortex:
 Arrests speech, impairs all facial movements
 Stim of areas in inferior, frontal, temporal,
parietal cortex:
 Impairs sequential facial movements, phoneme
identification
 Stim of other areas:
 lead to memory errors and reading errors
 Stim of thalamus during verbal input:
 increased accuracy of subsequent recall
Williams Syndrome
 Caused by the deletion of a dozen genes from
one of the two chromosomes numbered 7
 Shows dissociation between language and
intelligence, patients are:
 Fluent in language
 But cannot tie their shoe laces, draw images, etc.
 Developmental process is altered:
 Number skills good at infancy, poor at adulthood
 Language skills poor at infancy, greatly improved in
adulthood
Lateralization of the Brain
 Human body is asymmetrical: heart,
liver, use of limbs, etc.
 Functions of the brain become
lateralized
 Each hemisphere specialized for
particular ways of working
 Split-brain patients are good examples
of lateralization of language functions
Lateralization of functions
(approximate)
 Left-hemisphere:
 Sequential analysis
 Analytical
 Problem solving
 Language
 Right-hemisphere:
 Simultaneous analysis
 Synthetic
 Visual-Spatial skills
 Cognitive maps
 Personal space
 Facial recognition
 Drawing
 Emotional functions
 Recognizing emotions
 Expressing emotions
 Music
Split-brain
 Epileptic activity spread from one hemisphere
to the other thru corpus callosum
 Since 1930, such epileptic treated by
severing the interhemispheric pathways
 At first no detectible changes (e.g. IQ)
 Animal research revealed deficits:
 Cat with both corpus callosum and optic chiasm
severed
 Left-hemisphere could be trained for
symbol:reward
 Right-hemisphere could be trained for inverted
symbol:reward
Left vs. Right Brain
 Pre and post operation studies showed that:
 Selective stimulation of the right and left hemisphere
was possible by stimulating different parts of the body
(e.g. right/left hand):
 Thus can test the capabilities of each hemisphere
 Left hemisphere could read and verbally communicate
 Right hemisphere had small linguistic capacity:
recognize single words
 Vocabulary and grammar capabilities of right is far less
than left
 Only the processes taking place in the left hemisphere
could be described verbally

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Language disorders

  • 1. Language Disorders Medical and Psychosocial Aspects of Disability By: Hina Khalid
  • 2. Communication  There are 3 elements in this exchange, and all must be present: 1. Message 2. Message must be expressed 3. Message must be understood
  • 3.
  • 4. Speech and Language  Speech is the motor act of communicating by articulating verbal expression  Language is the knowledge of a symbol system used for interpersonal communication.
  • 5. Four domains of language Phonology Grammar Semantics Pragmatics
  • 6. Phonology  The ability to produce and discriminate the specific sounds of a given language.  Its unit, the phoneme, is characterized by distinctive features.  Babies start discriminating phonemes during the first few months of life, and they produce them soon after.
  • 7. Phonology  Phonological receptivity is pluripotential at birth  Starts to decay at around 10 months  Reaches a rather general inability to acquire native phonology by preadolescence
  • 8. Grammar  The underlying rules that organize any specific language.  The combinatorial rules that most native speakers of a language recognize as acceptable for that language and that allow a native speaker an infinite array of generative possibilities.
  • 9. Grammar  Composed of both morphology and syntax.
  • 10. Semantics  The study of meaning  Includes the study of vocabulary (lexicon).
  • 11. Lexicon  Lexical entries are organized in the mental dictionary according to well- defined rules  Allows the young child to acquire a peak average of 10 new words per day.  By 24 months the average child knows 50 words.
  • 12. Lexicon Growth  The subsequent exponential growth makes it difficult to determine vocabulary size with exactitude.
  • 13. Environmental factors predicting large vocabularies  Reading and discussing children's stories  The quality of dinner table conversations  Large mother-produced number of words  Higher socioeconomic status (SES)  Being the firstborn ( Hoff-Ginsberg, 1998 )  Quantity and sophistication of mother's vocabulary ( Snow, 1998 ).
  • 14. Pragmatics  A number of sub-domains reflecting communicative competence.
  • 15. Sub domains of Pragmatics  Rules of conversation (turn-taking, topic maintenance, conversational repair)  Politeness  Narrative and extended discourse  The implementation of communicative intents
  • 16. Pragmatic disorders  Little variety in language use  May say inappropriate or unrelated things during conversations  May tell stories in a disorganized way  Can often make demands, ask questions, and greet people  Has trouble organizing language to talk about what happened in the past.
  • 17. Pragmatic disorders  Appear to pull topics out of the air  May not use statements that signal a change in topic, such as "That reminds me."  Peers may avoid having conversations with such a child.  Can lower social acceptance.
  • 18. Language Developmental Trajectory Canonical Babbling Word comprehension Word production Word combinations Telegraphic speech
  • 19. Continue…..  By age 3, most normal children have mastered the basic structures of their native language
  • 20. Language acquisition  Occurs with uniformity and rapidity  Supports the hypothesized existence of innate, genetically determined Universal Grammars  Recently proposed a combination of traditional learning and innate language modules.
  • 21. Disfluencies in Children  Almost all children go through a stage of frequent disfluency  usually between the ages of 2 and 5.  Speech is produced easily in spite of the disfluencies.
  • 22. Etiology of Speech & Language Disorders  Mental retardation  Hearing loss  Maturation delay (developmental language delay)  Expressive language disorder (developmental expressive aphasia)  Bilingualism  Psychosocial deprivation  Autism  Elective mutism  Receptive aphasia  Cerebral palsy
  • 23. Overview of major types of speech disordersspeech disorders  Definitions vary, but generally agree that speech disorders involve deviations of sufficient magnitude to interfere with communication.  They draw attention to the speaking act and away from the message
  • 24. 1. Fluency Disorders  Speech is characterized by repeated interruptions, hesitations, or repetitions  Stuttering is by far the most well- known fluency disorder
  • 25. 1. Stuttering  Flow of speech is abnormally interrupted by repetitions, blocking, or prolongations of sounds, syllables, words, or phrases  Very familiar, but actually quite rare – only 1-5% of the population.  Articulation disorders actually occur much more frequently than stuttering
  • 26. Stuttering -- Causes  Still a mystery  Three perspectives: 1. Symptom of emotional disturbance 2. Result of biological makeup 3. Learned response
  • 27. Stuttering  Disorder of speech fluency that interrupts the forward flow of speech.  All individuals are disfluent at times  Differentiated by the kind and amount of the disfluencies
  • 28. Characteristics-Repetition  Sounds  b-b-b-ball  Syllables  mo-mo-mommy  Parts of words  basket-basket-basketball  Whole words, and phrases
  • 29. Characteristics-Prolongation  Stretching, of sounds or syllables  r-----abbit
  • 30. Characteristics  Tense pauses, hesitations, and/or no sound between words  Speech that occurs in spurts  as the child tries to initiate or maintain voice  Variability in stuttering behavior  depending on the speaking situation
  • 31. Related behaviors  tense muscles in the lips, jaw, and/or neck  tremor of the lips, jaw, and/or tongue  foot tapping  eye blinks  head turns
  • 32. 2. Articulation disorders  This is the largest category of all speech problems  DSM-IV calls these “phonological disorders.”  “abnormal speech-sound production, characterized by inaccurate or otherwise inappropriate execution of speaking”
  • 33. 2. Articulation disorders  Great majority are functional articulation disorders  Might represent as much as 80% of the speech disorders diagnosed by speech clinicians  Must be very careful to distinguish true problems from delay.  E.g., r, s, th problems may largely disappear naturally after 5 years of age
  • 34. 2. Articulation disorders 1. Omissions 2. Substitutions 3. Additions 4. Distortions
  • 35. 3. Voice disorders  Unusual or abnormal acoustical qualities in the sounds made when a person speaks  Very little research here  What is a “normal” sounding voice?  Nasality, hoarseness, breathiness
  • 37. 4. Delayed speech  Failure to develop speech at the expected age  Somewhat subjective  Usually associated with other maturational delays  May also be associated with a hearing impairment, mental retardation, emotional disturbance, or brain injury  Often the result of environmental deprivation
  • 38. Epidemiology of Speech Delay  Common childhood problem  Affects 3 to 10 percent of children.  3-4X more common in boys than in girls.
  • 39. Most common causes of speech delay Mental retardation Hearing loss Maturation delay
  • 40. Overview of major types of language disorderslanguage disorders  Need to understand normal language and prelanguage development  See Table 10.1 on 320  May involve comprehension (understanding) or expression in written or spoken language  These are very complex to diagnose and treat
  • 42. Language disordersLanguage disorders 1. Expressive language disorders 2. Receptive language disorders 3. Aphasia – loss of the ability to speak or comprehend language because of an injury or developmental abnormality in the brain
  • 43. EXPRESSIVE LANGUAGE DISORDER (developmental expressive aphasia)  Fail to develop the use of speech at the usual age.
  • 44. EXPRESSIVE LANGUAGE DISORDER  Normal intelligence  Normal hearing  Good emotional relationships  Normal articulation skills.  Comprehension of speech is appropriate to the age of the child
  • 45. EXPRESSIVE LANGUAGE DISORDER  Brain dysfunction that results in an inability to translate ideas into speech.
  • 46. EXPRESSIVE LANGUAGE DISORDER  The child is at risk for language-based learning disabilities (dyslexia).  May use gestures to supplement their limited verbal expression .
  • 47. Maturation Delay vs. Expressive Language Disorder?  The late bloomer will eventually develop normal speech  The child with an expressive language disorder will not do so without intervention.
  • 48. Maturation Delay vs. Expressive Language Disorder? It is sometimes difficult, if not impossible, to distinguish at an early age a late bloomer from a child with an expressive language disorder.
  • 49. BILINGUALISM  A bilingual home environment may cause an apparent temporary delay in the onset of both languages.
  • 50. BILINGUALISM  The bilingual child's comprehension of the two languages is normal for a child of the same age.  Usually becomes proficient in both languages before the age of five years.
  • 51. Interference or transfer  An English error due to the direct influence of the primary language structure.  This is a normal phenomenon
  • 52. Silent period  Common second-language acquisition phenomenon  Often very quiet, speaking little  Focus on understanding the new language  The younger the child, the longer the silent period tends to last.
  • 53. Code switching  Changing languages over phrases or sentences.  Normal phenomenon
  • 54. Benefits of Bilingualism  Children who are fluent bilinguals actually outperform monolingual speakers on tests of metalinguistic skill.
  • 55. Benefits of Bilingualism  Our world is shrinking and business becomes increasingly international  Children who are fluent bilingual speakers are potentially a tremendously valuable resource for the U.S. economy.
  • 56. Language Disorders  Egyptians reported speech loss after blow to head 3000 years ago  Broca (1861) finds damage to left inferior frontal region (Broca’s area) of a language impaired patient, in postmortem analysis
  • 57. Language Disorders  In language disorders  90-95% of cases, damage is to the left hemisphere  5-10% of cases, to the right hemisphere  Wada test is used to determine the hemispheric dominance  Sodium amydal is injected to the carotid artery  First to the left and then to the right
  • 58.
  • 59. Language Disorders  Paraphasia:  Substitution of a word by a sound, an incorrect word, or an unintended word  Neologism:  Paraphasia with a completely novel word  Nonfluent speech:  Talking with considerable effort  Agraphia:  Impairment in writing  Alexia:  Disturbances in reading
  • 60. Three major types of Aphasia Rosenzweig: Table 19.1, p. 615  Borca’s aphasia  Nonfluent speech  Wernicke’s aphasia  Fluent speech but unintelligible  Global aphasia  Total loss of language Others: Conduction, Subcortical, Transcortical Motor/Sensory (see also Kandel, Table 59-1)
  • 61. Brain areas involved in Language
  • 62. Broca’s Aphasia Brodmann 44, 45  Lesions in the left inferior frontal region (Broca’s area)  Nonfluent, labored, and hesitant speech  Most also lost the ability to name persons or subjects (anomia)  Can utter automatic speech (“hello”)  Comprehension relatively intact  Most also have partial paralysis of one side of the body (hemiplegia)  If extensive, not much recovery over time
  • 63. Wernicke’s Aphasia Brodmann 22, 30  Lesions in posterior of the left superior temporal gyrus, extending to adjacent parietal cortex  Fluent speech  But contains many paraphasias  “girl”-“curl”, “bread”-“cake”  Syntactical but empty sentences  Cannot repeat words or sentences  Unable to understand what they read or hear  Usually no partial paralysis
  • 64. Wernicke-Geschwind Model 1. Repeating a spoken word  Arcuate fasciculus is the bridge from the Wernicke’s area to the Broca’s area
  • 65. Wernicke-Geschwind Model 2. Repeating a written word  Angular gyrus is the gateway from visual cortex to Wernicke’s area  This is an oversimplification of the issue:  not all patients show such predicted behavior (Howard, 1997)
  • 66. Sign Languages  Full-fledged languages, created by hearing- impaired people (not by Linguists):  Dialects, jokes, poems, etc.  Do not resemble the spoken language of the same area (ASL resembles Bantu and Navaho)  Pinker: Nicaraguan Sign Language  Another evidence of the origins of language (gestures)  Most gestures in ASL are with right-hand, or else both hands (left hemisphere dominance)  Signers with brain damage to similar regions show aphasia as well
  • 67. Signer Aphasia  Young man, both spoken and sign language:  Accident and damage to brain  Both spoken and sign languages are affected  Deaf-mute person, sign language:  Stroke and damage to left-side of the brain  Impairment in sign language  3 deaf signers:  Different damages to the brain with different impairments to grammar and word production
  • 68. Spoken and Sign Languages  Neural mechanisms are similar  fMRI studies show similar activations for both hearing and deaf  But in signers, homologous activation on the right hemisphere is unanswered yet
  • 69. Dyslexia  Problem in learning to read  Common in boys and left-handed  High IQ, so related with language only  Postmortem observation revealed anomalies in the arrangement of cortical cells  Micropolygyria: excessive cortical folding  Ectopias: nests of extra cells in unusual location  Might have occurred in mid-gestation, during cell migration period
  • 70. Acquired Dyslexia = Alexia  Disorder in adulthood as a result of disease or injury  Deep dyslexia (pays attn. to wholes):  “cow” -> “horse”, cannot read abstract words  Fails to see small differences (do not read each letter)  Problems with nonsense words  Surface dyslexia (pays attn. to details):  Nonsense words are fine  Suggests 2 different systems:  One focused on the meanings of whole words
  • 71. Electrical Stimulation  Penfield and Roberts (1959): During epilepsy surgery under local anesthesia to locate cortical language areas, stimulation of:  Large anterior zone:  stops speech  Both anterior and posterior temporoparietal cortex:  misnaming, impaired imitation of words  Broca’s area:  unable comprehend auditory and visual semantic material,  inability to follow oral commands, point to objects, and understand written questions
  • 72. Studies by Ojemann et al.  Stimulation of the brain of an English-Spanish bilingual shows different areas for each language  Stim of inferior premotor frontal cortex:  Arrests speech, impairs all facial movements  Stim of areas in inferior, frontal, temporal, parietal cortex:  Impairs sequential facial movements, phoneme identification  Stim of other areas:  lead to memory errors and reading errors  Stim of thalamus during verbal input:  increased accuracy of subsequent recall
  • 73. Williams Syndrome  Caused by the deletion of a dozen genes from one of the two chromosomes numbered 7  Shows dissociation between language and intelligence, patients are:  Fluent in language  But cannot tie their shoe laces, draw images, etc.  Developmental process is altered:  Number skills good at infancy, poor at adulthood  Language skills poor at infancy, greatly improved in adulthood
  • 74. Lateralization of the Brain  Human body is asymmetrical: heart, liver, use of limbs, etc.  Functions of the brain become lateralized  Each hemisphere specialized for particular ways of working  Split-brain patients are good examples of lateralization of language functions
  • 75. Lateralization of functions (approximate)  Left-hemisphere:  Sequential analysis  Analytical  Problem solving  Language  Right-hemisphere:  Simultaneous analysis  Synthetic  Visual-Spatial skills  Cognitive maps  Personal space  Facial recognition  Drawing  Emotional functions  Recognizing emotions  Expressing emotions  Music
  • 76. Split-brain  Epileptic activity spread from one hemisphere to the other thru corpus callosum  Since 1930, such epileptic treated by severing the interhemispheric pathways  At first no detectible changes (e.g. IQ)  Animal research revealed deficits:  Cat with both corpus callosum and optic chiasm severed  Left-hemisphere could be trained for symbol:reward  Right-hemisphere could be trained for inverted symbol:reward
  • 77. Left vs. Right Brain  Pre and post operation studies showed that:  Selective stimulation of the right and left hemisphere was possible by stimulating different parts of the body (e.g. right/left hand):  Thus can test the capabilities of each hemisphere  Left hemisphere could read and verbally communicate  Right hemisphere had small linguistic capacity: recognize single words  Vocabulary and grammar capabilities of right is far less than left  Only the processes taking place in the left hemisphere could be described verbally

Editor's Notes

  1. Remember Bernard Shaw's word ghoti with the gh from laugh, the o from women and the ti from nation and pronounced 'fish'?
  2. The word unladylike consists of three morphemes and four syllables. Morpheme breaks: un- 'not' lady '(well behaved) female adult human' -like 'having the characteristics of' None of these morphemes can be broken up any more without losing all sense of meaning. Lady cannot be broken up into "la" and "dy," even though "la" and "dy" are separate syllables. Note that each syllable has no meaning on its own.
  3. A person who stutters may experience more fluency in the speech-language pathologist' s office than in a classroom or workplace. There may be no difficulty making a special dinner request at home, but extreme difficulty ordering a meal in a restaurant. Conversation with a spouse may be easier, and more fluent, than that with a boss. A person may be completely fluent when singing, but experience significant stuttering when talking on the telephone.
  4. A person who stutters may experience more fluency in the speech-language pathologist' s office than in a classroom or workplace. There may be no difficulty making a special dinner request at home, but extreme difficulty ordering a meal in a restaurant. Conversation with a spouse may be easier, and more fluent, than that with a boss. A person may be completely fluent when singing, but experience significant stuttering when talking on the telephone.
  5. 1 to 6 months Coos in response to voice 6 to 9 months Babbling 10 to 11 months Imitation of sounds; says "mama/dada" without meaning 12 months Says "mama/dada" with meaning; often imitates two- and three-syllable words 2 to ½ years Vocabulary of 400 words, including names; two- to three-word phrases; use of pronouns; diminishing echolalia; 75% of speech understood by strangers
  6. The primary deficit appears to be a brain dysfunction that results in an inability to translate ideas into speech.
  7. Because this disorder is not self-correcting, active intervention is necessary
  8. Maturation delay is a much more common cause of speech delay Expressive language disorder accounts for only a small percentage of cases.
  9. In Spanish, "esta casa es mas grande" means "this house is bigger." The literal translation would be "this house is more bigger." A Spanish-speaking child who said "this house is more bigger" would be manifesting transfer from Spanish to English.
  10. "Me gustaria manejar-I' ll take the car!" ("I' d like to drive-I' ll take the car"). Spanish "With my teacher, I have utang ng loob [debt of gratitude] because she has been so good to me." Filipino
  11. During a Wada, the neuroradiologist puts one side of your brain to sleep for a few minutes. This is done by injecting sodium amobarbital (also called sodium amytal) into the right or left internal carotid artery. If the right carotid artery is injected, the right side of the brain goes to sleep and can't communicate with the left side. Once the physicians are sure that one side of your brain is asleep, the neuropsychologist shows you objects and pictures. The awake side of the brain tries to recognize and remember what it sees. After just a few minutes, the sodium amobarbital wears off. The side that was asleep starts to wake up. Once both sides of your brain are fully awake, the neuropsychologist will ask you what was shown. If you don't remember what you saw, items are shown one at a time, and you are asked whether you saw each one before. Your responses will be recorded word-for-word. After a delay, the other side of the brain is put to sleep. To do this, the catheter is withdrawn part of the way and threaded into the internal carotid artery on the other side. A new angiogram is done for that side of the brain. Different objects and pictures are shown, and the awake side (which was asleep before) tries to recognize and remember what it sees. Once both sides are awake again, you will be asked what was shown the second time. Then you are shown items one at a time and asked whether you just saw each item. How long does the test take?The Wada test can vary between medical centers. In some centers, the delay between the injections is 30 to 60 minutes. Other centers test one side on one day, and test the other side the following day. Between five and twelve items are shown to each side of the brain. You may come in and leave the same day, or you may be asked to come in the day before or stay a day after. Is the Wada safe?A Wada test is generally a safe procedure with very few risks. There is a small risk of some complications. These complications can be as minor as pain where the catheter is inserted or as serious as a potential stroke. Since the Wada involves entering arteries, there is a chance that fat inside an artery may come loose and cause a blockage in the brain, leading to a stroke. This risk of stroke is less than 1% overall. It is greater, but still relatively low, if you are older or if you have atherosclerosis (hardening of the arteries) or a history of high cholesterol.