this is my first and new slide

1. By:Dr.Govind singh jadon
PGDACR&PV
PHARMACODYNAMIC & G-
PROTIEN COUPLE RECEPTOR

2. Contents
1. Introduction of pharmacodynamic.
2. Types of receptors.
3. Mechanism of drug action.
4. Introduction of GPCR.
5. Diagram of GPCR.
6. Mechanism of GPCR.
7. Example of drug in GPCR

3. Defination:-
 pharmakon: Drug

dynamiks : force or power
 pharmacodynamics is the study of the effects
of drugs on the body.

4. Types of receptors
 Type 1: L ( ionotropic receptors)
 Type 2: G protein-coupled
receptors (metabotropic)
 Type 3: Kinase-linked and related receptors
 Type 4: Nuclear receptors

5. Mechanism of drug action
 chemical properties
 cellular receptor (intra cellular or extracellular)
 enzymes
 others

6. G protein
G protein also known as guanine nucleotide-
binding proteins, involved in transmitting
signals and function as molecular switches.
G protein-coupled receptors (GPCRs), also
known as seven-transmembrane domain
receptors, 7T receptors, serpentine receptor,
G protein-linked receptors (GPLR).
It constitute a largeprotein family of receptors
that sense molecules outside the cell and
activate inside signal transduction pathways
and ultimately cell responses.

7. They are called seven-transmembrane receptors
because they pass through the cell membrane seven
times.
Humans express over 800 GPCRs that make up
the third largest familyof genes in humans.
GPCRs are the target of many drugs; perhaps half
of all non-antibiotic prescription drugs at the se
receptors.
G protein complexes are Made up
1.23 aplha (α)
2.7 beta (β)
3.12 gamma (ʏ ) subunits.

8. G-protein couple receptor

9. Mechanism of GCPR

10. Example of drug in GPCR
 examples of GPCRs include beta-
adrenergicreceptors, which bind epinephrine;
prostaglandin E 2receptors, which bind
inflammatory substances called
prostaglandins; and rhodopsin, which contains
a photoreactive chemical called retinal that
responds to light signals received by rod cells
in the eye.

12. THANK YOU