Inclusion body hepatitis–hydropericardium syndrome (IBH–HPS), is an emerging poultry disease in recent times characterized by sudden onset with a high mortality.

1. DR. MD. KUMRUL HASSAN
Executive, VSD
SQUARE Pharmaceuticals Ltd.
Agrovet Division
PRESENTED BY

2. Immunity, Health & Production
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• Consumer confidence, product quality & safety, emergence & re-
emergence of diseases, antibiotic resistance - major challenges to
current situation and strategic future
It is essential to know that chickens are not susceptible to intranasal infection by
the SARS-CoV-2 (COVID-19) virus.

3. Inclusion Body Hepatitis
Acute infectious disease characterized
by typical hydropericardium, severe
anaemia, necrotic hepatitis and high
mortality
Also called as Angara, Hydropericardium
syndrome, hepato nephrosis complex,
Litchi Heart disease etc 3
Introduction

4. Adenovirus strain K31/89
“Inclusion Body” - little dark dots in
nucleus of liver cells under
microscop
“Hepatitis” - liver swells and
become discoloured.
“Hydro pericardium” - water in
pericardium
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Introduction

5. • 1st described in USA (1963) than
Canada, UK, Australia, Italy,
France, Ireland, Pakistan (1987)
• Affected birds may not exhibit any
clinical signs except sudden heavy
mortality
• Morbidity 1 - 10%, Mortality 15 - 60%
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Epidemiology
• Mostly affects young birds between 2 - 5 weeks of age and
occasionally layer and breeder pullets also

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• Transmitted both vertically and horizontally
• Course of 9- 15 days as infected birds remain carriers
for a few weeks.
• Resistant to environmental factors and easily
transmitted by a mechanical route.
• Immune system damage from IBD can help to push
these broiler flocks into full-blown IBH disease.
Adenoviruses are very common in the
poultry environment
Transmission

7. Signs - symptoms, PM lesions, ELISA, Agar Gel diffusion ,
Immunoelectrophoresis, PCR test helps to specific diagnosis
Symptoms
• Depression, Anorexia & Inappetance
• Ruffled feathers, Pallor comb & wattles
• Chalky gray to bright light yellow mucoid droppings
• Anemia and dehydration may develop secondary to
hemorrhagic enteritis
• Sometimes skin become icteric
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8. Typical viral particles can be detected from feces, liver, spleen,
kidney, or other affected tissues.
Post-Mortem Lesions
• Febrile carcass similar to gumboro and fowl typhoid
• Liver swollen, yellow, mottled with petechlae and Ecchymoses
• Kidneys enlarged, pale and mottled with multiple hemorrhages
• Blood thin and bone marrow pale
• Pericardium sac is distended with fluid.
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• Vaccination (N/A in BD)
• Strictly maintain biosecurity
• Good water sanitation
• Eggs of broiler parent flocks, affected progeny,
should not be used for hatching.
• Treatment of drinking water with 0.1% - 2.5%
Viodin Vet solution appears to be beneficial.
Supportive care: Limit stress: Call veterinarian
Control & Prevention

10. Avian Adenoviruses do not naturally infect mammals
and therefore no public health implications exist.
Use Antiviral
Preparations
Andopan Use NephroImmunomodulators
Nephrocare
Use Liver tonic with Choline chloride,
except B1 or Herbal Preparation
Toxol Liquid / Digestim Avoid giving Sulpha drug
Use Amprium* 10
Balanced Feed
Supply grain with amino acid
& Low Protein
Treatment

11. Any
Questions ?
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12. Regards –
Dr. Md. Kumrul Hassan
Phone:
+88 017 9999 8674
Email:
Kumrul.hassan@squaregroup.com