This document discusses 3D printing of pharmaceuticals. It provides a brief history of 3D printing, describing important developments from 1984 to 2011. It then discusses challenges in 3D printing technology and types of 3D printers such as nozzle-based deposition systems and selective laser sintering. Advantages include rapid prototyping and low production costs, while disadvantages include size limitations and high energy usage. The document concludes by discussing future prospects for 3D printing such as personalized medicine and examples of 3D printed drug products and dosages that have been approved by the FDA.

1. PROJECT REPORTS ON 3D PRINTING
ISF COLLEGE OF PHARMACY, MOGA 1
ASSIGNMENT REPORT ON
“3D PTINTINGS OF PHARMACEUTICALS”
UNDER PERSONALIZED MEDICINES,
I.K. GUJRAL PUNJAB TECHNICAL UNIVERSITY JALANDHAR
SUBMITTED BY :- SUBMITTED TO :-
ATULCHAUDHARY Dr. CHARAN SINGH
STUDENT ASSOCIATE PROFESSOR
M.PHARMIstYEAR PHARMACEUTICS
I.S.F. COLLEGE OF PHARMACY GHAL
KALAN, MOGA, PUNJAB 142048

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3DPRINTINGOFPHARMACEUTICALS
INTRODUCTIN:-
The 3D printing process builds a three-dimensional object from a computer-aided design (CAD)
model, usually by successively adding material layer by layer, why it is also called additive
manufacturing, and unlike conventional machining, casting and forging processes, where
material is removed from a stock item or poured into a mold and shaped by means of dies, presses
and hammers.
3D printing or additive manufacturing, creates physical objects from a geometrical representation
by successive addition of materials.
Since the time of its inception, 3D printing has not only fascinated the researchers but also health
professionals.
HISTORY :-

3. PROJECT REPORTS ON 3D PRINTING
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AIM:-
Though the process is exciting, it involves meticulous coordination and selection process to achieve
a desirable product. Emphasis has also been laid to recognize the best suitable product and ways to
prevent its misuse.
GENERALPRINCIPLES:-
3D printable models may be created with a computer-aided design (CAD) package, via a 3D
scanner, or by a plain digital camera and photogrammetric software. 3D printed models created
with CAD result in reduced errors and can be corrected before printing, allowing verification in the
design of the object before it is printed.
1984-86
• Charles Hull was Invents priniting and coins the term Stereo
Lithography
1992 • First 3D Printer built by 3D system
1999
• First application of 3D printing in the medical field creating
the human bladder
2006
• The selective laser sintering machine - printing multiple
materials & fields
2011
• 3D printers start offering 14k gold as printable materials

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CHALLENGES IN 3D PRINTING TECHNOLOGY :-
The technology is still under the developing stage. Hence it undergoes several challenges such as
optimization process, improving performance of device for versatile use, selections of appropriate
excipients, post treatment method, etc.
To improve the performance of 3D printed products and to expand the application range in novel
drug delivery systems.
TYPES OF PRINTERS :-
NOZAL BASED
DEPOSITION SYST.
PRESSURE ASSOCIATED
MICROSYRING HOT MELT PRINTING
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NOZAL BASED DEPOSITION SYSTEN :-
Nozzle-based deposition systems or Material extrusion: consist on the mixing of drugs and
polymers and other solid elements prior to 3D printing. The mixture is passed through a nozzle
that definitely originates, layer by layer, the three-dimensional product.
SELECTIVE LASER SINTERING :-
For metal 3D printing, see Selective Laser Sintering. An SLS machine being used at the Centro
Renato Archer in Brazil. Selective laser sintering (SLS) is an additive manufacturing (AM)
technique that uses a laser as In 2001, 3D Systems, the biggest competitor to DTM and SLS
technology, acquired DTM.
STEREOLITHOGRAPHY :-
Stereolithography (SLA or SL; also known as stereolithography apparatus, optical
fabrication, photo-solidification, or resin printing) is a form of 3D printing technology used for
creating models, prototypes, patterns, and production parts in a layer by layer fashion
using photochemical processes.
3D PRINTING MATERIALS :-
LASER BASED
WRITING SYSTEM
SELECTIVE LASER
SINTERING
STEREOLITHO
-GRAPHY
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ADVANTAGES :-
Rapid production of prototypes.
Low cost of production.
No storage cost.
Quick availability of organs.
Manufacturing speed.
DISADVANTAGES:-
Limitation of size.
High Energy Consumption.
Printing Technology is Expensive.
Harmful Emissions.
Production of Dangerous Weaponry.
METALS
• Stainless steel
• Gold
• Nickel
• Aluminium
• Titanium
• Silver
• Bronze
RESINS
• High DetailResins
• Paintable Resin
• Transparent Resin
PLASTIC
• PLA
• ABS
• PC
• PVA
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APPLICATIONS OF 3D PRINTING

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FUTUREPROSPECTS:-
Fabricate and engineer various novel dosage forms.
Achieve optimized drug release profiles.
Drug dosage forms, supporting delivery.
SOMEEXAMPLESOF 3DPRINTING MODELS:-
Bioprinting in Health Science
Drug Printing
USA-FDAapproved3Dprinteddrugproduct:-
In August 2015, Aprecia pharmaceuticals introduced the first drug product using the Zip Dose
technique for the treatment of epilepsy. FDA approved the drug product SPRITAM
levetiracetam for oral use for the treatment of partial seizures, primary generalized tonic
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clonic seizures, myoclonic seizures in adults and children. Spritam was formulated by Zip Dose
technology that produced a porous formulation that disintegrates rapidly. Spritam was designed
to fill the needs of the patients who have problems with the current medication therapy. Zip Dose
technology enables the incorporation of large doses up to 1000 mg in single dosage form. This
technology enhanced the patient compliance by easy administration of drug. Zip Dose
technology combines the drug formulation science with unique manufacturing capabilities of 3D
printing. Aprecia pharmaceuticals have the FDA approved licence for developing the
pharmaceutical dosage form worldwide.
CONCLUSION :-
3D printing technology is a growing trend towards advanced drug delivery. This technology has
the built-in flexibility of personalized and customized medicines. Moreover, it may transform the
conventional pharmacy practice by allowing medications to be truly individualized to a patient.
Furthermore, it enables preparation of dosage forms with accurate dose, shape and size control. It
can be assumed that in coming era 3DP can revolutionize the manufacturing processes of
pharmaceutical formulations with improved safety and efficacy.
REFERENCES:-
http://www.pharmaceutical-journal.com/news-and- analysis/features/3d-printing-the-future-of-
manufacturing- medicine/20068625.article .
http://en.wikipedia.org/wiki/3D_printing.
Visit www.seminarlinks.blogspot.in to Download.3
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