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1. NAME AND ID :
ADITI BHOWMICK
BPH 05106855
AMRIN JAHAN
BPH 05106857
LAMIA ABEDIN
BPH O5106864
ATIQUA HAQUE
BPH 05106869
PUROBEE BISWAS
BPH 05106845

2.  ACID REBOUND is a condition when antacid
causes our stomach to produce more acid ,
which worses our GI ( Gastrointestinal )
problems .

3.  ANTACIDS are alkaline base use to neutralize
the excess gastric hydrochloric acid
associated with gastritis and peptic ulcers .
 Its pH range of between 3-4 maintain during
antacid therapy .
 Approximate 98% of all stomach acid is
neutralize.

4.  ANTACIDS either ditectly neutralize acidity
by increasing the pH or reversibly decreases
or block the secretion of acid by gastric cells
to reduce acidity in the stomach when
gastric hydrochloric acid reaches the nerve in
the gastrointestinal mucosa , they signal pain
to the CNS . This happen when these nerves
are exposed .

6. We take antacid
 During heart burn
 Feeling uncomfortable for over eating
 Growing hungry feeling between meals

7.  When we take antacid it neutralize the excess
gastric hydrochloric acid and it inactivates
pepsin .
 Normally the stomach pH is 1-2.The optimal pH
for the proteolytic enzyme,pepsin.Most antacids
commonly raise the gastric pH to 4-5 , which
greatly reduce pepsin’s proteolytic action and
the gastric pH raised too much and acid rebound
may occur. To maintain pH ,stomach secrets
more HCl which consume the antacide . So for
this gastric content, including antacide in the
stomach will empty the intestine. As a result,
excess acid is secreted into stomach.
 It occurs in the stomach wall cell .

8.  Burning pain in the chest or upper abdomen
 Irritation in the throat
 Acid taste in the mouth
 Bad breath
 Causes nausea
 Difficult in swallaing.

9.  Excess of acid secretion into the stomach
leading to a possible hyperacidic condition
which further aggravate the ulcer .
 If antacid is sufficiently water soluble it
readily absorb ions and give its alkaline
effect , which is a problem for pepsin .
 Poor blood supply .
 It causes esophagatis.

10.  Withdrawal from acid-blocking proton pump
inhibitor (PPI) therapy .
 By decreasing the acidity of gastric juice by
activating pepsin .
 By reducing the volume of gastric juice .
 By surgerical procedure we can treat acid
rebound .

11.  LACTIC ACIDOSIS is a physiological condition
chracterized by decreasing pH in the body
tissue and blood .
 It build up of lactate, espically L-lactate and
distinct form of metabolic acidosis .

12. Signs and symptoms :
 Deep and rapid breath
 Vomiting
 Anxiety
 Abdominal pain
 Hypertention
Causes :
 Genetic condition
 Lactose 1,6-diphosphatase deficiency
 Due to K cyanide
 Due to hemorrhage
 Hypoxia

13. Direct removal of lactate from the body is
difficult, and there is limited evidence for
benefit .
 By using sodium bicarbonate solution to
improve pH .
 By using medication
 It may be treated with ketogenic diet and
possibly with dichloroacetate