FOR NURSING STUDENTS

1. ALIYA RAHMAN
PRIMARY
HYPERALDOSTERONISM
(CONN’S SYNDROME)

2. DEFINITION
 Clinical condition where there is hypersecretion of
aldosterone leading to sodium retension,
pottasium loss and hypertension

3. ETIOLOGY
 Adenoma of zona glomerulosa
 Bilateral hyperplasia of zona glomerulosa

4. PATHOPHYSIOLOGY
 ALDOSTERONISM
 Water and soidum retention, and volume
expansion
 Hypertension edema hypokalemia and loss of H+
ION
 Parasthesias, muscle wekness,depression of
tendon reflex, renal dysfunction
 hypernatremia, polyuria polydipsia, nocturia

5. CLINICAL FEATURES
 Hypertension
 Edema
 Hypokalemia
 Alkalosis
 Muscle weakness
 Abdominal distension
 Periodic muscle weakness
 Polyuria
 Tetany
 ECG changes and arrythmia

6. DIAGNOSIS
 Serum electrolyte
 Plasma/urinary aldosterone
 Pasma renin activity
 CT/MRI abdomen for adrenals

7. MANAGEMENT
 DRUG THERAPY – SPIRONOLACTONE( anti
aldosterone) 200-400mg/day+ ACE INHIBITOR
for hypertension
 SURGERY - UNILATERAL ADRENALECTOMY

8. Thank you