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SECONDARY
HYPERALDOSTERONISM
ALIYA RAHMAN
DEFINITION
 Common clinical condition occurs
secondary to some cause which stimulate
RAAS. It is either physiological or
pathological
ETIOLOGY
 Physiologic causes –
Salt depletion- inadequate salt intake,
excessive salt through kidney or GI
Pregnancy- progesterone stimulate
aldosterone production
 pathologic causes-
Hypoperfusion of kidney – nephrotic
syndrome, liver cirrhosis, CHF, diuretic
therapy
 Renal ischemia- malignant
hypertension,RAS
 High renin production by juxta glomerular
apparatus
DIAGNOSIS
 Plasma sodium level- normal or near
normal
 Plasma potassium level – low
 Plasma renin and aldosterone- elevated
MANAGEMENT
 TREAT UNDERLYING CAUSE
 Salt depletion- normal saline infusion
 Nephrotic syndrome, cirrohsis of liver CHF,
-SPIRONOLACTONE+ LOOP DIURETIC
 Renal ischemia- ACE INHIBITORS
 RAS- TRANSLUMINAL ANGIOPLASTY
 Diuretic therapy- use potassium sparing
diuretics.
THANK YOU

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Secondary hyperaldosteronism

  • 2. DEFINITION  Common clinical condition occurs secondary to some cause which stimulate RAAS. It is either physiological or pathological
  • 3. ETIOLOGY  Physiologic causes – Salt depletion- inadequate salt intake, excessive salt through kidney or GI Pregnancy- progesterone stimulate aldosterone production  pathologic causes- Hypoperfusion of kidney – nephrotic syndrome, liver cirrhosis, CHF, diuretic therapy
  • 4.  Renal ischemia- malignant hypertension,RAS  High renin production by juxta glomerular apparatus
  • 5. DIAGNOSIS  Plasma sodium level- normal or near normal  Plasma potassium level – low  Plasma renin and aldosterone- elevated
  • 6. MANAGEMENT  TREAT UNDERLYING CAUSE  Salt depletion- normal saline infusion  Nephrotic syndrome, cirrohsis of liver CHF, -SPIRONOLACTONE+ LOOP DIURETIC  Renal ischemia- ACE INHIBITORS  RAS- TRANSLUMINAL ANGIOPLASTY  Diuretic therapy- use potassium sparing diuretics.