10. Sudden loss of ability of the kidney to excrete wastes, concentrate urine, and conserve electrolytes. Evaluate for possible causes especially if potentially reversible. Acute tubular necrosis (Intra-renal) Infection (Pre-renal) Decreased blood flow (Pre-renal) trauma, complicated surgery, septic shock, hemorrhage, burns, dehydration Or poor intake Over exposure to metals, Solvents, radiographic contrast Materials, certain antibiotics (Intra-renal) Disorders of the blood or auto- Immune disorders (Intra-renal) Urinary Tract obstruction (Post-renal) Stricture of ureters, GU tumor, kidney Or ureteral stones, nephrocalcinosis Or enlarged prostate
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23. Progressive kidney function destruction (Surviving nephrons takes over the Function of loss) Glumerular Filtration Nephrons Hypertrophy Nephrons die (remaining one have increasingly difficult job) Decreased demand of Protein absorption for Remaining nephron Progressive loss Of nephrons, Scar tissue accumulates And renal blood flow reduced Loss of Excretory And non- Excretory Function CRF
