Janna Bastow discusses finding an effective product prioritization framework. She notes that there is no single perfect framework and recommends picking elements from different techniques like MoSCoW, impact vs effort matrix, and story mapping to create a hybrid approach. Bastow emphasizes focusing on the most important priorities rather than trying to prioritize all items at once. She also advocates using roadmapping to understand priorities and get team buy-in. The key is finding a framework that works best for each unique product and team.