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Immunodeficiency Disorders ,[object Object],[object Object],[object Object],[object Object]
Immunodeficiency Diseases Primary:   Usually congenital, resulting from genetic defects in some components of the immune system.  ,[object Object],[object Object],[object Object],[object Object]
Primary Immunodeficiency Diseases occur when there is a defect  in any one of the many steps  during lymphocyte development
Manifestations: ,[object Object],[object Object],[object Object]
Symptoms: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of Primary IDDs  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Aetiology ,[object Object],[object Object],[object Object],[object Object]
Primary B Cell Immunodeficiency  ,[object Object],[object Object]
X-linked Agammaglobulinaemia (XLA)/Bruton’s Disease: ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Selective IgA deficiency (IgA D) ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Severe Combined Immunodeficiency Disease (SCID) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
T Cell Immunodeficiency Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Primary T cell immunodefiency includes: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Di George Syndrome (Thymic Aplasia) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ataxia Telangiectasia (AT) ,[object Object],[object Object],[object Object],[object Object]
Wiskott-Aldrich Syndrome (WAS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acquired Immunodeficiency Syndrome/AIDS
What is HIV/AIDS? ,[object Object],[object Object],[object Object],[object Object]
What is HIV/AIDS ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The immune system army
What is the immune system? ,[object Object],[object Object],[object Object],[object Object]
How does HIV affect the immune system? ,[object Object],[object Object],[object Object],[object Object],[object Object]
What happens when the immune system is weakened?  ,[object Object],[object Object],[object Object]
What is AIDS? ,[object Object],[object Object],[object Object],[object Object]
What is the difference between “having HIV” and “having AIDS” ?  ,[object Object],[object Object],[object Object],[object Object]
Acquired Immunodeficiency Syndrome (AIDS) ,[object Object],[object Object]
PREVALENCE  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
History ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
HIV Tropism  ,[object Object],[object Object],[object Object],[object Object]
HIV Replication
Modes of transmission : ,[object Object],[object Object],[object Object],[object Object],Contaminated needles and syringes Contaminated instruments Blood and blood products
Mother to Child Transmission (MTCT) ,[object Object],[object Object]
HIV cannot be transmitted by: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Sources of infectious material ,[object Object],[object Object],[object Object],[object Object]
HIV Infection/AIDS Staging System ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immunopathological Mechanisms of HIV infection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pulmonary Infections: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gastrointestinal illness: ,[object Object],[object Object],[object Object]
Major neurological illnesses: ,[object Object],[object Object]
Malignancies: ,[object Object],[object Object],[object Object],[object Object]
Thank  you

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Immunodeficiency disorders,2010

Editor's Notes

  1. Actual prevalence remain elusive as many states does not report HIV infected persons and many persons are unaware of their HIV status.