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Mitotic Mistakes
 

Mitotic Mistakes

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    Mitotic Mistakes Mitotic Mistakes Presentation Transcript

    • Mitotic Mistakes What happens when things go wrong?
    • What is the big deal?
      • Although errors in mitosis are rare, the process may go wrong, especially during early cellular divisions in the zygote .
      • Mitotic errors can be especially dangerous to the organism because future offspring from this parent cell will carry the same disorder.
    • Different types of Errors
      • Non-Disjunction
      • Deletion
      • Translocation
      • Inversion
    • Deletion
      • Sometimes during mitosis the chromosomes can be damaged.
      • If the chromosome gets broken the fragments can be lost.
      • If this happens the genetic material they contain is deleted.
    • Translocation
      • If the chromosome breaks, it can reattach.
      • Sometimes it reattaches to the wrong chromosome.
      • This is called translocation
    • Inversion
      • When the fragment gets reattached it gets attached to the right chromosome but upside down.
      • When this happens it incorrected codes for information.
    • Non-Disjunction
      • When the sisters fail to separate.
      • One cell is given three copies (trisomy) of a chromosome while the other gets only one (monosomy).
      • These cells are called Aneuploidic, and they can cause cancer.
    • Aneuploidy
      • Most recognized forms of Aneuploidy are Downs Syndrome (Trisomy 21) and Edwards syndrome (Trisomy 18).
      • Different cells with abnormal amounts of chromosomes is called mosaicism.
      • Some forms of mosaicism can cause cancers of the white blood cells (luekemia).