Vitamin d

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Vitamin d

  1. 1. Vitamin D Submitted by:Prabhjot kaur
  2. 2. Introduction <ul><li>It is the collective name given to antirachitic substance. </li></ul><ul><li>These are synthesized in body and found in foods activated by UV radiation. </li></ul>
  3. 3. <ul><li>D1: mixture of antirachitic substances found in food. </li></ul><ul><li>D2: calciferol,present in irradiated food such as yeast ,fungi ,bread. </li></ul><ul><li>D3: cholecalciferol ,synthesized in skin under the influence of UV rays. </li></ul>
  4. 5. Action of calcitriol <ul><li>It enhances absorption of calcium and phosphate from intestine. </li></ul><ul><li>It enhances resorption of calcium and phosphate from bone </li></ul><ul><li>It enhances proximal tubular reabsorption of both calcium and phosphate in kidney </li></ul>
  5. 6. Vitamin D deficiency <ul><li>In this ,plasma calcium and phosphate tend to fall due to inadequate intestinal absorption. </li></ul><ul><li>Rickets in children </li></ul><ul><li>Osteomalacia in adults may occur. </li></ul>
  6. 7. Hypervitaminosis D <ul><li>It may occur due to chronic ingestion of large doses or due to increased sensitivity of tissues to vitamin D. </li></ul><ul><li>Hypercalcaemia,weakness,fatigue,vomiting,diarrhoea,renal stones,hypertension. </li></ul><ul><li>Even coma may occur. </li></ul>
  7. 8. Treatment <ul><li>Its dose should contain the vitamin,low calcium diet,plenty of fluid,and corticosteroid. </li></ul>
  8. 9. Uses <ul><li>In prophylaxis : in this prophylactic treatment may be given in obstructive jaundice and other conditions. </li></ul><ul><li>Metabolic rickets; these are group of condition in which the tissues does not give response to vit.D. </li></ul>
  9. 10. Vitamin D resistant rickets <ul><li>X linked heredity diseases in which vitamin d metabolism is normal and calcium and phosphate metabolism is deranged. </li></ul><ul><li>Phosphate with high dose of calcitrol. </li></ul>
  10. 11. Vitamin d dependent rickets <ul><li>It is a genetic disorder occur due deficiency of renal hydroxylating mechanism. </li></ul><ul><li>Normal doses of calciferol can v given </li></ul>
  11. 12. Renal rickets
  12. 13. <ul><li>Renal rickets: conversion of 25-OHD3 into calcitriol does not occur due to the chronic renal diseases. </li></ul><ul><li>In postmenopausal osteoporosis:it is an age related problem.in this there is decrease in calcium absorption from gut. </li></ul><ul><li>Vitamin D3 and calcium is used </li></ul>
  13. 14. Fanconi syndrome <ul><li>In this case vitamin d raise the lowered phosphate level that occur in this condition </li></ul>
  14. 15. Interactions <ul><li>Cholestyramine and chronic use of liquid paraffin can reduces vitamin d absorption. </li></ul><ul><li>Phenytoin and phenobarbitone reduces the responsiveness of target tissues to calcitriols. </li></ul><ul><li>Prolong uses of both may cause rickets and osteomalacia. </li></ul>

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