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Asthma Pathophysiologyn 1233730055155655 1
1.
Asthma Pathophysiology [email_address]
2.
3.
4.
Percent Change in
Age-Adjusted Death Rates, U.S., 1965-1998 06/16/09 0 0.5 1.0 1.5 2.0 2.5 3.0 Proportion of 1965 Rate 1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998 – 59% – 64% – 35% +163% – 7% Coronary Heart Disease Stroke Other CVD COPD All Other Causes
5.
Pathogenesis: 06/16/09 INFLAMMATION
Airflow Limitation SYMPTOMS Cough Wheeze Dyspnoea TRIGGERS Allergens, Exercise, Cold Air, SO2 Particulates Airway Hyperresponsiveness Genetic* INDUCERS Allergens,Chemical sensitisers, Air pollutants, Virus infections
6.
7.
Pathogenesis - Atopic
Asthma: 06/16/09
8.
Mast cells in
Asthma Pathogenesis: 06/16/09
9.
Eosinophils in Asthma
Pathogenesis: 06/16/09
10.
11.
Lung Hyperinflation in
Asthma 06/16/09
12.
Thick bronchi with
Mucous plugs 06/16/09
13.
Mucous plug in
asthma: 06/16/09
14.
15.
Asthma Microscopic Pathology
06/16/09 Obstructed Inflammed Bronchi
16.
17.
18.
Asthma – TH2
lymphocytes immunostaining) 06/16/09
19.
Eosinophils in Asthma:
06/16/09
20.
Curschmann's spirals: 06/16/09
21.
22.
06/16/09 5-LO inhibitors
Antileukotrienes Arachidonic Acid Leukotrienes LTC4, D4, E4 Cyclooxygenase 5-Lipoxygenase Prostaglandins Prostacyclins Cell Damage Cell Membrane Phospholipids Steroids NSAID
23.
24.
25.
06/16/09 Asthma Pathology
- Modern view Barnes PJ Leukotrienes C4, D4 & E4 Allergen Mucus hypersecretion Hyperplasia Vasodilatation New vessels Plasma leak Oedema Bronchoconstriction Hypertrophy/hyperplasia Cholinergic reflex Subepithelial fibrosis Sensory nerve activation Eosinophil Mast cell Th2 cell Neutrophil Macrophage/ dendritic cell Mucus plug Epithelial shedding Nerve activation
26.
06/16/09 Mast cell
Degranulation Barnes PJ Normal 5 Seconds 60 Seconds
27.
06/16/09 Mast cell
Degranulation Barnes PJ
28.
06/16/09 Type I
Hypersensitivity: Barnes PJ
29.
06/16/09 Therapy -
Pathology: Barnes PJ
30.
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