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Primary structure of protein Secondary structure of protein Tertiary structure of protein Quaternary structure of protein Methods to determine protein structure Conclusion References METHODS TO DETERMINE PROTEIN STRUCTURE Each protein has a unique sequence of amino acids. The amino acids are held together in a protein by covalent peptide bonds or linkages. A peptide bond are formed when amino group of an amino acid combines with the carboxyl group of another. The conformation of polypeptide chain by twisting or folding is referred to as secondary structure. Two types of secondary structures α-helix and β-sheet are mainly identified. α-Helical structure was proposed by Pauling and Corey in 1951. It occurs when the sequence of amino acids are linked by hydrogen bonds. Each turn of α-helix contains 3.6 amino acids. β-pleated sheets are composed of two or more segments of fully extended peptide chains. β-Sheets may be arranged either in parallel or anti-parallel direction. Many globular proteins contain combinations of α-helix and β-pleated sheet secondary structure, these patterns are called supersecondary structures also called motifs. The three dimensional arrangement of protein structure is referred to as tertiary structure. It is a compact structure with hydrophobic side chains held interior while the hydrophilic groups are on the surface. This type of arrangement provide stability of the molecule. Besides the H-bongs, disulfide bonds, ionic interactions, hydrophobic interactions also contribute to the tertiary structure.
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2024: Domino Containers - The Next Step. News from the Domino Container commu...
2024: Domino Containers - The Next Step. News from the Domino Container commu...
Phys 02 13
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![Objective 2.13 Levels of Protein Structure ,[object Object]](https://image.slidesharecdn.com/phys0213-100210131322-phpapp01/85/Phys-02-13-1-320.jpg)
![Protein Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)