16.1
General
Concepts
in
Immunity

Explain
the
basic
aspects
of
innate
(nonspecific)

and
adap?ve
(specific
or
acquired)
imm...
Three
Lines
of
Defense
in
the
Human

                     Body

•  Innate
immunity

    1st:
Barriers
at
body
surfaces
–
 ...
Innate
vs
Adap?ve

•  Innate
–
Nonspecific

  –  ATributes
we
have
at
birth

  –  Defend
us
from
all
pathogens

•  Adap?ve
...
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Chapter 16 Obj 01

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Chapter 16 Obj 01

  1. 1. 16.1
General
Concepts
in
Immunity
 Explain
the
basic
aspects
of
innate
(nonspecific)
 and
adap?ve
(specific
or
acquired)
immunity.
 •  What
are
the
first
lines
of
defense
against
 pathogens?
 •  What
are
the
second
lines
of
defense?
 •  What
is
the
third
line
of
defense
in
the
body?

  2. 2. Three
Lines
of
Defense
in
the
Human
 Body
 •  Innate
immunity
 1st:
Barriers
at
body
surfaces
–
 2nd:
Nonspecific
responses
–
 external

 internal

 •  Integument
&
mucous
 •  Phagocy?c
cells
 membranes
 •  Inflamma?on
&
fever
 •  Chemical
secre?ons
 •  microflora
 •  An?microbial
proteins
 •  3rd:
Adap?ve
immunity:
specific
immune
responses
 –  Cell‐mediated
 –  An?body‐mediated

  3. 3. Innate
vs
Adap?ve
 •  Innate
–
Nonspecific
 –  ATributes
we
have
at
birth
 –  Defend
us
from
all
pathogens
 •  Adap?ve
–
Acquired
–
Specific
 –  Not
present
at
birth
 –  Immune
responses
that
develop
aWer
exposure
 •  Vaccine,
subclinical
infec?on,
clinical
infec?on
 –  Unique
cells
for
each
specific
pathogen


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