Molecular Genetics

Molecular Genetics The Central Dogma of Biology

What is a Genetic “Factor”? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Requirements of Genetic Material ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chromosomes – The First Clue ,[object Object],[object Object],[object Object],[object Object],[object Object]

Chromosome Observations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Importance of Sex Chromosomes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What Carries the Genetic Information? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Discovery of DNA ,[object Object],[object Object],[object Object]

The Transforming Principle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Transforming Principle is DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Hershey-Chase Experiment ,[object Object],[object Object],[object Object],[object Object],[object Object]

The Experiment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Experiment Summary ,[object Object],[object Object],[object Object],[object Object]

Results Summary ,[object Object],[object Object],[object Object]

Chargaff’s Rule ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Base Pairing in DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Double Helix ,[object Object],[object Object],[object Object],[object Object]

Watson and Crick shared the 1962 Nobel Prize for Physiology and Medicine with Maurice Wilkins. Rosalind Franklin died before this date.

DNA Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Messelson and Stahl ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Experiment ,[object Object],[object Object],[object Object],[object Object]

The expected results for each model were:

The actual results were as expected for the semiconservative model and thus Watson and Crick's suspicion was borne out.

Enzymes & Replication ,[object Object],[object Object],[object Object],[object Object]

The Enzymes of DNA Replication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Single-stranded Binding Proteins ,[object Object],[object Object],[object Object]

Beginning: Origins of Replication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Elongation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DNA Polymerase ,[object Object],[object Object],[object Object],[object Object],[object Object]

Proofreading & Repair ,[object Object],[object Object]

DNA Strands are Anti-parallel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Why 5’  3’? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Leading & Lagging Strands ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Building the Lagging Strand ,[object Object],[object Object],[object Object],[object Object]

Ligase ,[object Object],[object Object],[object Object],[object Object]

Primers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Primase ,[object Object],[object Object],[object Object],[object Object]

Ending the Strand ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Telomeres ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Telomerase ,[object Object],[object Object],[object Object],[object Object],[object Object]

Further Proofreading & Repair ,[object Object],[object Object],[object Object],[object Object]

Nucleotide Excision & Repair ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Molecular Genetics

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Molecular Genetics