Papillary thyroid carcinoma is the most common type of thyroid cancer, accounting for 75-80% of cases. Microscopically, it is characterized by solid white firm lesions that are often multifocal with calcification. Under the microscope, it displays complex, branching papillae lined by cuboidal cells with overlapping nuclei resembling "Orphan Annie Eyes" along with nuclear grooves, intranuclear inclusions, psammoma bodies, and possible squamous metaplasia.

1. Papillary thyroid Carcinoma
• 75-80%
• Women
• Men

2. Gross
• Solid
• White
• Firm
• Often multifocal
• Calcification

3. Microscopic
• Complex, branching, randomly oriented
papillae with fibrovascular cores
• Papillae lined by cuboidal cells with moderate
to abundant cytoplasm,
• Nuclei are overlapping, with optically clear
chromatin – “Orphan Annie Eye”

4. • Nuclear grooves
• Eosinophilic intranuclear inclusions
• Psammoma bodies within the fibrovascular
cores
• Squamous metaplasia